Evidence map›Paper›PMID 35031925›Full record

ReviewMolecular biology reports2022

Kinases and therapeutics in pathogen mediated gastric cancer.

Charu Sonkar, Nidhi Varshney, Siva Koganti, Hem Chandra Jha

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Charu SonkarInfectious Bioengineering Lab, Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore, Madhya Pradesh, 453552, India.
Nidhi VarshneyInfectious Bioengineering Lab, Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore, Madhya Pradesh, 453552, India.
Siva KogantiCentral for Advanced Research, SVIMS, Tirupathi and Omicron laboratories, Vijaywada, India.
Hem Chandra JhaInfectious Bioengineering Lab, Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore, Madhya Pradesh, 453552, India. hemcjha@iiti.ac.in.ORCID http://orcid.org/0000-0002-9698-4547
Indian Institute of Technology Indore · INSri Venkateswara Institute of Medical Sciences · IN

Funding

Science and Engineering Research Board EMR/2017/001637Science and Engineering Research Board SB/S2/RJN-132/20/5
6 · The paper itself

Abstract

introductionMany pathogens have coexisted with humans for millennia and can cause chronic inflammation which is the cause of gastritis. Gastric cancer (GC) is associated with 8.8% of cancer related deaths, making it one of the leading causes of cancer related deaths worldwide. This review is intended to give brief information about Helicobacter pylori (H. pylori), Epstein-Barr virus (EBV), human cytomegalovirus (HCMV) role in GC and associated kinases. These organisms can trigger multiple cellular pathways aiming for unnatural cellular proliferation, apoptosis, migration and inflammatory response. Kinases also can activate and deactivate the signalling leading to aforementioned pathways. Therefore, studying kinases is inevitable. MATERIAL AND

methodsThis review is the comprehensive collection of information from different data sources such as journals, book, book chapters and verified online information.

conclusionKinase amplifications could be used as diagnostic, prognostic, and predictive biomarkers in various cancer types. Hence targeting kinase and related signalling molecules could be considered as a potential approach to prevent cancer through these organisms. Here we summarize the brief information about the role of kinases, signalling and their therapeutics in GC concerning H. pylori, EBV and HCMV.

Indexed as

Epstein-Barr Virus InfectionsHelicobacter InfectionsHelicobacter pyloriStomach NeoplasmsHerpesvirus 4, HumanHumansEBVGastric cancerHCMVH. pyloriKinases

Identifiers

PMID35031925
OpenAlexW4206130482

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.