Evidence map›Paper›PMID 35031861›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2022

Non-specific spondylodiscitis: a new perspective for surgical treatment.

Nicola Giampaolini, Massimo Berdini, Marco Rotini, Rosa Palmisani, Nicola Specchia, Monia Martiniani

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In one paragraph

Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Spondylodiscitis of lumbar complicated with spinal epidural abscess caused byZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nicola GiampaoliniClinica Ortopedica dell'Adulto e Pediatrica, AOU "Ospedali Riuniti di Ancona", Ancona, Italy.
Massimo BerdiniClinica Ortopedica dell'Adulto e Pediatrica, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Di.S.Cli.Mo., Via Tronto 10/A, 60020, Ancona, Torrette, Italy. m.berdini@pm.univpm.it.ORCID http://orcid.org/0000-0003-2545-0625
Marco RotiniClinica Ortopedica dell'Adulto e Pediatrica, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Di.S.Cli.Mo., Via Tronto 10/A, 60020, Ancona, Torrette, Italy.
Rosa PalmisaniClinica Ortopedica dell'Adulto e Pediatrica, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Di.S.Cli.Mo., Via Tronto 10/A, 60020, Ancona, Torrette, Italy.
Nicola SpecchiaClinica Ortopedica dell'Adulto e Pediatrica, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Di.S.Cli.Mo., Via Tronto 10/A, 60020, Ancona, Torrette, Italy.ORCID http://orcid.org/0000-0001-8710-378X
Monia MartinianiClinica Ortopedica dell'Adulto e Pediatrica, AOU "Ospedali Riuniti di Ancona", Ancona, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePyogenic spondylodiscitis is a relatively rare spinal disease; non-specific spondylodiscitis (NSS) cases are increasing. This study aims to identify if changes of inflammatory markers under antibiotic therapy can be used to determine which NSS patients can benefit from surgical indication earlier than others.

methodsTwo groups of patients with NSS were examined. Group A underwent surgery, while Group B was treated conservatively. Group B was also subdivided in patients undergoing antibiotic therapy for > 6 weeks (B1) and < 6 weeks (B2). Groups were compared for age, gender, BMI, blood levels of ESR and CRP and VAS scale.

resultsThere were no differences (P = 0.06) in reduction in ESR at 4 weeks between two main groups. A reduction in CRP, with < 2.7 mg/dl at 4 weeks, was observed in Group A (P = 0.01). Comparing Group B1 to B2, a reduction (P = 0.0001) in VAS, ESR and CRP at 4 weeks was observed in Group B2. It was possible to isolate the pathogen in 52.8% of Group B, without any differences on VAS, ESR and CRP values and on length of the antibiotic therapy.

conclusionsThe surgical treatment should be considered for patients who, after 4 weeks of conservative therapy, do not show a reduction in the ESR < 50 mm/h and of the CRP < 2.7 g/dl. The comparison between groups underwent surgically and those treated conservatively showed a reduction in the CRP at 4 weeks and better VAS for pain at 3 months in Group A.

Indexed as

DiscitisAnti-Bacterial AgentsHumansPainRetrospective StudiesTreatment OutcomeAnti-Bacterial AgentsAntibiotic treatment of spondylodiscitisESR, CRPNon-specific spondylodiscitisPyogenic spondylodiscitisVertebral osteomyelitis

Identifiers

PMID35031861

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.