Evidence map›Paper›PMID 35031818›Full record

ArticleInternational orthopaedics2022

Factors associated with failure of surgical revision and IV antibiotics to resolve Cutibacterium periprosthetic infection of the shoulder.

Corey J Schiffman, Zachary D Mills, Jason E Hsu, Anastasia J Whitson, Frederick A Matsen Iii

Abstract read
PubMed Publisher
In one paragraph

Article in International orthopaedics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Corey J SchiffmanDepartment of Orthopedics and Sports Medicine, University of Washington, Box 356500, 1959 NE Pacific Street, WA, 98195-6500, Seattle, USA.ORCID http://orcid.org/0000-0002-5891-5196
Zachary D MillsDepartment of Orthopedics and Sports Medicine, University of Washington, Box 356500, 1959 NE Pacific Street, WA, 98195-6500, Seattle, USA.ORCID http://orcid.org/0000-0002-9923-2068
Jason E HsuDepartment of Orthopedics and Sports Medicine, University of Washington, Box 356500, 1959 NE Pacific Street, WA, 98195-6500, Seattle, USA.ORCID http://orcid.org/0000-0002-1411-3482
Anastasia J WhitsonDepartment of Orthopedics and Sports Medicine, University of Washington, Box 356500, 1959 NE Pacific Street, WA, 98195-6500, Seattle, USA.ORCID http://orcid.org/0000-0002-4426-6164
Frederick A Matsen IiiDepartment of Orthopedics and Sports Medicine, University of Washington, Box 356500, 1959 NE Pacific Street, WA, 98195-6500, Seattle, USA. matsen@uw.edu.ORCID http://orcid.org/0000-0002-6465-4826
University of Washington · USSeattle Pacific University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCutibacterium is the most common organism causing shoulder periprosthetic infection (PJI). While most shoulder PJIs are well treated by prosthesis exchange and antibiotics, in some cases this treatment fails to resolve the infection. The factors associated with these failures have not been previously identified. The aim of this study was to identify the characteristics of patients with failure of treatment for PJI.

methodsThirty-five patients suspected of having Cutibacterium PJI had revision arthroplasty with single-stage implant exchange followed by intravenous antibiotics. The characteristics of those with ≥ two positive cultures at revision surgery were compared to those who did not. The characteristics of those patients having a re-revision with ≥ two positive deep cultures (documented treatment failures) were compared to those who did not.

resultsThe 17 patients that had ≥ two positive cultures at their index revision were more likely to be male, to have had ream and run procedures, and to have higher loads of Cutibacterium on pre-operative cultures of their unprepared skin. The five patients that had documented treatment failure had higher loads of Cutibacterium on their skin and in deep cultures obtained at their index revision.

conclusionPatients harboring high loads of Cutibacterium on their unprepared skin prior to revision and high loads of Cutibacterium on deep cultures at the time of their index revision are at increased risk for failure of implant exchange and antibiotics to resolve a Cutibacterium PJI.

Indexed as

Arthroplasty, Replacement, ShoulderProsthesis-Related InfectionsAnti-Bacterial AgentsFemaleHumansMaleReoperationRetrospective StudiesShoulderAnti-Bacterial AgentsCutibacteriumFailureIntravenous antibioticsPeriprosthetic infectionRevision surgery

Identifiers

PMID35031818
OpenAlexW4206023520

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.