Evidence map›Paper›PMID 35031808›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2022

Trabecular bone score and its association with Cobb angle kyphosis in older men: a cross-sectional study for the Osteoporotic Fractures in Men (MrOS) Study.

R Patel, J Shen, J F Nichols, J T Schousboe, G N Woods, W B Katzman, D M Kado

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 1 country.

R PatelDepartment of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
J ShenHerbert Wertheim School of Public Health and Human Longevity Sciences, University of California San Diego, La Jolla, CA, USA.
J F NicholsHerbert Wertheim School of Public Health and Human Longevity Sciences, University of California San Diego, La Jolla, CA, USA.
J T SchousboePark Nicollet Clinic and Health Partners Institute and University of Minnesota, Minneapolis, MN, USA.
G N WoodsDepartment of Medicine, University of California San Diego and VA San Diego Health Care System, La Jolla, CA, USA.
W B KatzmanUniversity of California, San Francisco, San Francisco, CA, USA.
D M KadoDepartment of Medicine, Stanford University, Stanford, California and VA Palo Alto, Palo Alto, CA, USA. dkado@stanford.edu.
Human Longevity (United States) · USPark Nicollet Clinic · USStanford University · USUC San Diego Health System · USUniversity of California, Los Angeles · USUniversity of California, San Diego · USUniversity of California, San Francisco · US

Funding

Oregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7M
Osteoporotic Fractures in Men (MrOS) - San Francisco Coordinating CenterU01AR066160 · NIAMS · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON · 2013 to 2017
$9.3M
Osteoporotic Fractures in Men (MrOS) - MinneapolisU01AG042145 · NIA · UNIVERSITY OF MINNESOTA · PI ENSRUD, KRISTINE · 2013 to 2019
$5.3M
Osteporotic Fractures in Men (MrOS)- Admin CenterU01AG027810 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2017
$5.1M
Osteoporotic Fractures in Men (MrOS) - PortlandU01AG042124 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2013 to 2019
$3.0M
Osteoporatic Fractures in Men (MrOS)U01AG042168 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KADO, DEBORAH · 2013 to 2017
$3.0M
Osteoporotic Fractures in Men (Mr. Os) Palo AltoU01AG042143 · NIA · STANFORD UNIVERSITY · PI STEFANICK, MARCIA L. · 2013 to 2017
$3.0M
Osteoporotic Fractures in Men (Mr.OS)U01AG042139 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAULEY, JANE ANN · 2013 to 2017
$2.9M
Osteoporotic Fractures in Men_MrOS Renewal_BirminghamU01AG042140 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SHIKANY, JAMES M · 2013 to 2019
$2.7M
BIOLOGICAL AND STRUCTURAL PREDICTORS OF KYPHOSIS PROGRESSION IN OLDER MENR01AR060828 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KADO, DEBORAH · 2011 to 2013
$1.0M
Causes and Consequences of Hyperkyphosis in Older WomenR01AG024246 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KADO, DEBORAH · 2004 to 2007
$978k
Causes and Consequences of Hyperkyphosis in Older PersonsR56AG024246 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KADO, DEBORAH · 2009 to 2009
$395k
NCATS NIH HHS UL1 TR000128NIAMS NIH HHS AR066160NIAMS NIH HHS R01 AR060828NIAMS NIH HHS U01 AR066160NIA NIH HHS AG024246NIA NIH HHS AG027810NIA NIH HHS AG042124NIA NIH HHS AG042139NIA NIH HHS AG042140NIA NIH HHS AG042143NIA NIH HHS AG042145NIA NIH HHS AG042168NIA NIH HHS R01 AG024246NIA NIH HHS U01 AG027810NIA NIH HHS U01 AG042124NIA NIH HHS U01 AG042139NIA NIH HHS U01 AG042140NIA NIH HHS U01 AG042143NIA NIH HHS U01 AG042145NIA NIH HHS U01 AG042168NIH HHS TR000128
6 · The paper itself

Abstract

Hyperkyphosis (HK), or accentuated forward spinal curvature, commonly affects older people, although its causes are not completely understood. We tested whether a measure of bone quality, trabecular bone score (TBS), is associated with HK in 1997 older men, and determined that men with degraded TBS were more likely to have HK.

introductionWhile vertebral fractures and low bone mineral density (BMD) contribute to kyphosis progression, it is unknown whether the trabecular bone score (TBS) may provide additional information on bone quality that could influence the degree of kyphosis. We hypothesized that degraded TBS would be associated with hyperkyphosis (HK) defined as a Cobb angle > 50°.

methodsUsing data from 1997 participants of the Osteoporotic Fractures in Men (MrOS) Study who had baseline TBS and Cobb angle kyphosis measured, we investigated whether men with degraded TBS were more likely to be hyperkyphotic, even after adjustment for BMD and prevalent vertebral fractures.

resultsMen were an average age of 74 ± 6 (mean ± SD) years with a mean kyphosis angle of 38.6 ± 11.5°, 295 (15%) were classified as hyperkyphotic, and 416 (21%) had degraded TBS. Compared with men with TBS > 1.2, men with degraded TBS were more likely to have HK (OR: 1.47, 95% CI: 1.06-2.06, p = 0.02) after adjusting for age, clinic, race, BMI, hip BMD, and prevalent vertebral fracture. If spine instead of hip BMD was included in the model, the odds ratio decreased to 1.35 (95% CI: 0.97-1.89, p = 0.08).

conclusionsOlder men with degraded TBS are more likely to have HK not explained by underlying vertebral fractures.

Indexed as

KyphosisOsteoporotic FracturesSpinal FracturesAbsorptiometry, PhotonAgedAged, 80 and overBone DensityCancellous BoneCross-Sectional StudiesHumansLumbar VertebraeMaleBone mineral densityHyperkyphosisKyphosisTrabecular bone scoreVertebral fractures

Identifiers

PMID35031808
PMCPMC9010364
OpenAlexW4205392831

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.