Observational studyInternational journal of obesity (2005)2022
Associations between body composition, fat distribution and metabolic consequences of excess adiposity with severe COVID-19 outcomes: observational study and Mendelian randomisation analysis.
Observational study in International journal of obesity (2005), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Prevalence and clinical implications of abnormal body composition phenotypes in patients with COVID-19: a systematic review.The American journal of clinical nutrition · 2023Pooled it
- Adiposity and infection-related mortality: Mendelian randomization study of 126 000 Mexican adults.International journal of epidemiology · 2026Article
- Identifying direct risk factors in UK Biobank via simultaneous Bayesian-frequentist model-averaged hypothesis testing using Doublethink.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Assessing the causal effects of type 2 diabetes and obesity-related traits on COVID-19 severity.Human genomics · 2025Article
- Web-based high-intensity bodyweight interval training improves metabolic health and physical fitness outcomes in middle-aged men with obesity during the COVID-19 pandemic.Frontiers in physiology · 2025Article
- Adiposity and mortality among intensive care patients with COVID-19 and non-COVID-19 respiratory conditions: a cross-context comparison study in the UK.BMC medicine · 2024Article
- Unravelling the obesity maze in diabetic patients: A comparative analysis of classification methods.Journal of family medicine and primary care · 2024Article
- Cardiovascular autonomic evaluation and body fat analysis in COVID-19-recovered patients in Dakshina Kannada, India.Journal of education and health promotion · 2024Article
- Interwoven challenges of covid-19, poor diet, and cardiometabolic health.BMJ (Clinical research ed.) · 2023Article
- A framework for assessing selection and misclassification bias in mendelian randomisation studies: an illustrative example between body mass index and covid-19.BMJ (Clinical research ed.) · 2023Article
- Association Between Diabetes Severity and Risks of COVID-19 Infection and Outcomes.Journal of general internal medicine · 2023Article
- The association of dietary insulin load and dietary insulin index with body composition among professional soccer players and referees.BMC sports science, medicine & rehabilitation · 2023Article
- The impact of obesity: a narrative review.Singapore medical journal · 2023Review
- Article
- UK biobank: Enhanced assessment of the epidemiology and long-term impact of coronavirus disease-2019.Cambridge prisms. Precision medicine · 2023Review
- COVID-19 and sarcopenia-related traits: a bidirectional Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Low muscle mass and high visceral fat mass predict mortality in patients hospitalized with moderate-to-severe COVID-19: a prospective study.Endocrine connections · 2022Article
- Progressive Additive Benefits of Prehabilitation and Subsequent Bariatric Surgery on Cardiac Autonomic Regulation as Assessed by Means of a Simple Unitary Composite Index: Preliminary Data from an Observational Study.Journal of personalized medicine · 2022Article
- Causal associations between body fat accumulation and COVID-19 severity: A Mendelian randomization study.Frontiers in endocrinology · 2022Article
- Therapeutic targets and functions of curcumol against COVID-19 and colon adenocarcinoma.Frontiers in nutrition · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHigher body mass index (BMI) and metabolic consequences of excess weight are associated with increased risk of severe COVID-19, though their mediating pathway is unclear.
methodsA prospective cohort study included 435,504 UK Biobank participants. A two-sample Mendelian randomisation (MR) study used the COVID-19 Host Genetics Initiative in 1.6 million participants. We examined associations of total adiposity, body composition, fat distribution and metabolic consequences of excess weight, particularly type 2 diabetes, with incidence and severity of COVID-19, assessed by test positivity, hospital admission, intensive care unit (ICU) admission and death.
resultsBMI and body fat were associated with COVID-19 in the observational and MR analyses but muscle mass was not. The observational study suggested the association with central fat distribution was stronger than for BMI, but there was little evidence from the MR analyses than this was causal. There was evidence that strong associations of metabolic consequences with COVID-19 outcomes in observational but not MR analyses. Type 2 diabetes was strongly associated with COVID-19 in observational but not MR analyses. In adjusted models, the observational analysis showed that the association of BMI with COVID-19 diminished, while central fat distribution and metabolic consequences of excess weight remained strongly associated. In contrast, MR showed the reverse, with only BMI retaining a direct effect on COVID-19.
conclusionsExcess total adiposity is probably casually associated with severe COVID-19. Mendelian randomisation data do not support causality for the observed associations of central fat distribution or metabolic consequences of excess adiposity with COVID-19.
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