ArticleNature communications2022
Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants.
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Rethinking schizophrenia: insights from genomics and implications for research.Molecular psychiatry · 2026Review
- R-loops shape the H2A.Z landscape and promote balanced lineage allocation during differentiation.Genome research · 2026Article
- Transcriptomic identification and developmental mapping ofTurkish journal of biology = Turk biyoloji dergisi · 2026Article
- Multiscale Permutation Time Irreversibility Analysis of MEG in Patients with Schizophrenia.Entropy (Basel, Switzerland) · 2025Article
- Persistent cortical excitatory neuron dysregulation in adultResearch square · 2025Article
- Autism risk genes converge onbioRxiv : the preprint server for biology · 2025Article
- Autism- and intellectual disability-associated MYT1L mutation alters human cortical interneuron differentiation, maturation, and physiology.Stem cell reports · 2025Article
- Brain-derived tau oligomer polymorphs: distinct aggregations, stability profiles, and biological activities.Communications biology · 2025Article
- Minding the gap between artificial and biological computing paradigms for biologically loyal AI.Frontiers in systems neuroscience · 2025Article
- Genetic Heterogeneity in Four Probands RevealsBiomedicines · 2024Article
- Novel splicing variant and gonadal mosaicism in DYRK1A gene identified by whole-genome sequencing in multiplex autism spectrum disorder families.Neurogenetics · 2024Article
- Single cell spatial biology over developmental time can decipher pediatric brain pathologies.Neurobiology of disease · 2024Review
- Genetic Implication of Prenatal GABAergic and Cholinergic Neuron Development in Susceptibility to Schizophrenia.Schizophrenia bulletin · 2024Article
- Comprehensive network modeling approaches unravel dynamic enhancer-promoter interactions across neural differentiation.Genome biology · 2024Article
- Comprehensive network modeling approaches unravel dynamic enhancer-promoter interactions across neural differentiation.bioRxiv : the preprint server for biology · 2024Article
- RFX4 is an intrinsic factor for neuronal differentiation through induction of proneural genes POU3F2 and NEUROD1.Cellular and molecular life sciences : CMLS · 2024Article
- A mild impairment in reversal learning in a bowl-digging substrate deterministic task but not other cognitive tests in the Dlg2+/- rat model of genetic risk for psychiatric disorder.Genes, brain, and behavior · 2023Article
- Distinct H3K27me3 and H3K27ac Modifications in Neural Tube Defects Induced by Benzo[a]pyrene.Brain sciences · 2023Article
- Neurodevelopmental disorders-high-resolution rethinking of disease modeling.Molecular psychiatry · 2023Review
- CRISPR/Cas-Based Approaches to Study Schizophrenia and Other Neurodevelopmental Disorders.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 1 country.
Bret SandersNeuroscience and Mental Health Research Institute, Cardiff University, Cardiff, CF24 4HQ, UK.
Daniel D'AndreaMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, CF24 4HQ, UK.ORCID http://orcid.org/0000-0002-7843-3856
Mark O CollinsDepartment of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK.ORCID http://orcid.org/0000-0002-7656-4975
Elliott ReesMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, CF24 4HQ, UK.
Tom G J StewardBristol Medical School, University of Bristol, Bristol, BS1 3NY, UK.ORCID http://orcid.org/0000-0002-7515-1706
Ying ZhuNeuroscience and Mental Health Research Institute, Cardiff University, Cardiff, CF24 4HQ, UK.
Gareth ChapmanNeuroscience and Mental Health Research Institute, Cardiff University, Cardiff, CF24 4HQ, UK.
Sophie E LeggeMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, CF24 4HQ, UK.ORCID http://orcid.org/0000-0001-6617-0289
Antonio F PardiñasMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, CF24 4HQ, UK.ORCID http://orcid.org/0000-0001-6845-7590
Adrian J HarwoodNeuroscience and Mental Health Research Institute, Cardiff University, Cardiff, CF24 4HQ, UK.
William P GrayNeuroscience and Mental Health Research Institute, Cardiff University, Cardiff, CF24 4HQ, UK.ORCID http://orcid.org/0000-0001-7595-8887
Michael C O'DonovanMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, CF24 4HQ, UK.ORCID http://orcid.org/0000-0001-7073-2379
Michael J OwenNeuroscience and Mental Health Research Institute, Cardiff University, Cardiff, CF24 4HQ, UK.ORCID http://orcid.org/0000-0003-4798-0862
Adam C ErringtonNeuroscience and Mental Health Research Institute, Cardiff University, Cardiff, CF24 4HQ, UK.
Derek J BlakeMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, CF24 4HQ, UK.ORCID http://orcid.org/0000-0002-5005-4731
Daniel J WhitcombBristol Medical School, University of Bristol, Bristol, BS1 3NY, UK.ORCID http://orcid.org/0000-0003-2703-1643
Andrew J PocklingtonMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, CF24 4HQ, UK. pocklingtonaj@cardiff.ac.uk.ORCID http://orcid.org/0000-0002-2137-0452
Eunju ShinNeuroscience and Mental Health Research Institute, Cardiff University, Cardiff, CF24 4HQ, UK. e.shin@keele.ac.uk.ORCID http://orcid.org/0000-0002-8865-6834
Cardiff University · GBUniversity of Bristol · GBKeele University · GBUniversity of Sheffield · GB
Funding
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MNATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8MAlzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MCollaborative GWAS of Dementia, AD and related MRI and Cognitive EndophenotypesR01AG033193 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SESHADRI, SUDHA · 2009 to 2016
$4.4MMedical Research Council 503480Medical Research Council G0300356Medical Research Council G08005009Medical Research Council MR/L010305/1NHLBI NIH HHS R01 HL105756NIA NIH HHS R01 AG033193NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG032984NIA NIH HHS U24 AG021886Wellcome TrustWellcome Trust 082604/2/07/ZWellcome Trust (Wellcome) 100202/Z/12/Z
Abstract
Coordinated programs of gene expression drive brain development. It is unclear which transcriptional programs, in which cell-types, are affected in neuropsychiatric disorders such as schizophrenia. Here we integrate human genetics with transcriptomic data from differentiation of human embryonic stem cells into cortical excitatory neurons. We identify transcriptional programs expressed during early neurogenesis in vitro and in human foetal cortex that are down-regulated in DLG2
Indexed as
Gene Expression Regulation, DevelopmentalNeurogenesisAnimalsCell DifferentiationCerebral CortexFemaleGene Knockdown TechniquesGenetic Predisposition to DiseaseGuanylate KinasesHuman Embryonic Stem CellsHumansMental DisordersNeuronsPregnancySchizophreniaTranscriptomeDLG2 protein, humanGuanylate KinasesTumor Suppressor Proteins
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