ArticleNature communications2022
Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice.
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed, 69 citations in OpenAlex.
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- Siglec-F Protects Against Elastase-induced Lung Inflammation and Emphysema in Mice.bioRxiv : the preprint server for biology · 2025Article
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- MTMR14 depletion aggravates intrapulmonary inflammation and emphysema in experimental COPD through activating macrophage M1 polarization.Respiratory research · 2025Article
- TRPML2 in distinct states reveals the activation and modulation principles of the TRPML family.Nature communications · 2025Article
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- Targeting BRD4 ameliorates experimental emphysema by disrupting super-enhancer in polarized alveolar macrophage.Respiratory research · 2025Article
- Advances on the Role of Lung Macrophages in the Pathogenesis of Chronic Obstructive Pulmonary Disease in the Era of Single-Cell Genomics.International journal of medical sciences · 2025Review
- TPC2: From Blond Hair to Melanoma?Cancers · 2024Review
- Rab7a is an enhancer of TPC2 activity regulating melanoma progression through modulation of the GSK3β/β-Catenin/MITF-axis.Nature communications · 2024Article
- MFSD7C protects hemolysis-induced lung impairments by inhibiting ferroptosis.Nature communications · 2024Article
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Authors and funding
33 authors at 11 institutions in 5 countries.
Barbara SpixWalther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany.
Elisabeth S ButzDepartment of Pharmacy, Ludwig-Maximilians-University, Munich, Germany.
Cheng-Chang ChenDepartment of Pharmacy, Ludwig-Maximilians-University, Munich, Germany.
Anna Scotto RosatoWalther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany.
Rachel TangWalther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany.
Aicha JeridiComprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
Veronika KudrinaWalther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany.ORCID http://orcid.org/0000-0002-3762-8673
Eva PleschDepartment of Pharmacy, Ludwig-Maximilians-University, Munich, Germany.
Philipp WartenbergSaarland University, Center for Molecular Signaling (PZMS), Experimental Pharmacology, Homburg, Germany.
Elisabeth ArltWalther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany.
Daria BriukhovetskaDivision of Clinical Pharmacology, Department of Medicine IV, University Hospital Munich, Munich, Germany.
Meshal AnsariComprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.ORCID http://orcid.org/0000-0002-8819-7965
Gizem Günes GünselComprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
Thomas M ConlonComprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.ORCID http://orcid.org/0000-0002-4316-6612
Amanda WyattSaarland University, Center for Molecular Signaling (PZMS), Experimental Pharmacology, Homburg, Germany.ORCID http://orcid.org/0000-0003-1107-3857
Sandra WetzelInstitute of Biochemistry, Christian-Albrechts-University Kiel, Kiel, Germany.
Daniel TeupserInstitute of Laboratory Medicine, University Hospital Munich, Munich, Germany.
Lesca M HoldtInstitute of Laboratory Medicine, University Hospital Munich, Munich, Germany.
Fabien EctorsFARAH Mammalian Transgenics Platform, Liège University, Liège, Belgium.ORCID http://orcid.org/0000-0003-2846-7019
Ingrid BoekhoffWalther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany.
Ulrich BoehmSaarland University, Center for Molecular Signaling (PZMS), Experimental Pharmacology, Homburg, Germany.
Jaime García-AñoverosDepartments of Anesthesiology, Physiology and Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-6561-9048
Paul SaftigInstitute of Biochemistry, Christian-Albrechts-University Kiel, Kiel, Germany.ORCID http://orcid.org/0000-0003-2637-7052
Martin GieraCenter for Proteomics and Metabolomics, Leiden University Medical Center, 2333ZA, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-1684-1894
Sebastian KoboldDivision of Clinical Pharmacology, Department of Medicine IV, University Hospital Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-5612-4673
Herbert B SchillerComprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.ORCID http://orcid.org/0000-0001-9498-7034
Susanna ZierlerWalther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany.
Thomas GudermannWalther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany.
Christian Wahl-SchottInstitute for Neurophysiology, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0002-7514-2367
Franz BracherDepartment of Pharmacy, Ludwig-Maximilians-University, Munich, Germany.ORCID http://orcid.org/0000-0003-0009-8629
Ali Önder YildirimComprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany. oender.yildirim@helmholtz-muenchen.de.ORCID http://orcid.org/0000-0003-1969-480X
Martin BielDepartment of Pharmacy, Ludwig-Maximilians-University, Munich, Germany. martin.biel@cup.uni-muenchen.de.ORCID http://orcid.org/0000-0002-9974-3052
Christian GrimmWalther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany. christian.grimm@med.uni-muenchen.de.ORCID http://orcid.org/0000-0002-0177-5559
Ludwig-Maximilians-Universität München · DEHelmholtz Zentrum München · DEMünchen Klinik · DESaarland University · DEChristian-Albrechts-Universität zu Kiel · DEMedizinische Hochschule Hannover · DEGerman Center for Lung Research · DELeiden University Medical Center · NLNational Taiwan University · TWNorthwestern University · USUniversity of Liège · BE
Funding
Outer and Inner Hair Cell DevelopmentR01DC015903 · NIDCD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Jaime Garcia-Anoveros · 2017 to 2026
$5.8MLysosomes in neonatal enterocytes and their pathologiesR01DK111032 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GARCIA-ANOVEROS, JAIME · 2016 to 2019
$1.4MNIDCD NIH HHS R01 DC015903NIDDK NIH HHS R01 DK111032
Abstract
Lung emphysema and chronic bronchitis are the two most common causes of chronic obstructive pulmonary disease. Excess macrophage elastase MMP-12, which is predominantly secreted from alveolar macrophages, is known to mediate the development of lung injury and emphysema. Here, we discovered the endolysosomal cation channel mucolipin 3 (TRPML3) as a regulator of MMP-12 reuptake from broncho-alveolar fluid, driving in two independently generated Trpml3
Indexed as
AnimalsDisease Models, AnimalEndosomesFemaleHumansLungMacrophages, AlveolarMatrix Metalloproteinase 12MiceMice, KnockoutPancreatic ElastasePulmonary EmphysemaTransient Receptor Potential ChannelsMatrix Metalloproteinase 12Mcoln3 protein, mousePancreatic ElastaseTransient Receptor Potential Channels
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.