ArticleProceedings of the National Academy of Sciences of the United States of America2022
Targeted vaccination and the speed of SARS-CoV-2 adaptation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Global disparities in COVID-19 vaccine coverage associated with trajectories of SARS-CoV-2 adaptation.BMC infectious diseases · 2026Article
- Simulating targeted vaccination strategies with network-based and agent-based models: A scoping review.PLOS global public health · 2026Article
- The speed of vaccination rollout and the risk of pathogen adaptation.Journal of the Royal Society, Interface · 2025Article
- Evolution of parasite transmission dispersion.Royal Society open science · 2025Article
- Prioritising older individuals for COVID-19 booster vaccination leads to optimal public health outcomes in a range of socio-economic settings.PLoS computational biology · 2024Article
- Policy makers believe money motivates more than it does.Scientific reports · 2024Article
- Utilizing river and wastewater as a SARS-CoV-2 surveillance tool in settings with limited formal sewage systems.Nature communications · 2023Article
- Vaccine hesitancy promotes emergence of new SARS-CoV-2 variants.Journal of theoretical biology · 2023Article
- Temporal, age, and geographical variation in vaccine efficacy against infection by the Delta and Omicron variants in the community in France, December 2021 to March 2022.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023Article
- Immune Response to Vaccination against COVID-19 at Different Second-Dose Intervals and Their Associations with Metabolic Parameters.Vaccines · 2023Article
- Data-driven scalable pipeline using national agent-based models for real-time pandemic response and decision support.The international journal of high performance computing applications · 2023Article
- Antigenic escape is accelerated by the presence of immunocompromised hosts.Proceedings. Biological sciences · 2022Article
- Pathogen evolution during vaccination campaigns.PLoS biology · 2022Article
- Effects of epistasis and recombination between vaccine-escape and virulence alleles on the dynamics of pathogen adaptation.Nature ecology & evolution · 2022Article
- Targeted vaccination and the speed of SARS-CoV-2 adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The limited supply of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raises the question of targeted vaccination. Many countries have opted to vaccinate older and more sensitive hosts first to minimize the disease burden. However, what are the evolutionary consequences of targeted vaccination? We clarify the consequences of different vaccination strategies through the analysis of the speed of viral adaptation measured as the rate of change of the frequency of a vaccine-adapted variant. We show that such a variant is expected to spread faster if vaccination targets individuals who are likely to be involved in a higher number of contacts. We also discuss the pros and cons of dose-sparing strategies. Because delaying the second dose increases the proportion of the population vaccinated with a single dose, this strategy can both speed up the spread of the vaccine-adapted variant and reduce the cumulative number of deaths. Hence, strategies that are most effective at slowing viral adaptation may not always be epidemiologically optimal. A careful assessment of both the epidemiological and evolutionary consequences of alternative vaccination strategies is required to determine which individuals should be vaccinated first.
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