ArticleNeuroImage2022
Functional connectome of arousal and motor brainstem nuclei in living humans by 7 Tesla resting-state fMRI.
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- A systematic review of associations between functional connectivity, mood and cognition in patients with irritable bowel syndrome.Brain imaging and behavior · 2026Pooled it
- Evidence for domain-general arousal from semantic and neuroimaging meta-analyses reconciles opposing views on arousal.Proceedings of the National Academy of Sciences of the United States of America · 2025Pooled it
- Orofacial Central Pattern Generators: Neuroanatomical and Clinical Insights into Sensory, Motor, Emotional Integration.Experimental neurobiology · 2026Review
- The Co-Evolution of Sleep and Diet: Toward an Emerging Framework of Evolutionary Chrononutrition in Circadian-Metabolic Health.Nutrients · 2026Review
- Convulsive-Like Movements in Posterior Circulation Large Vessel Occlusion: Associations With Midbrain Injury and Poor Outcome.CNS neuroscience & therapeutics · 2026Article
- Structure-function coupling in the human brainstem.bioRxiv : the preprint server for biology · 2026Article
- Whole-brain efferent projections of glutamatergic neurons in the cingulate cortex of mice.Molecular brain · 2026Article
- Caffeine as an Ergogenic Aid for Neuromuscular Performance: Mechanisms of Action from Brain to Motor Units.Nutrients · 2026Review
- Evaluating the quality of brainstem ROI registration using structural and diffusion MRI.Frontiers in neuroscience · 2026Article
- MRI-derived atrophy in multiple system atrophy aligns with mitochondrial and glial gene expression patterns.NPJ Parkinson's disease · 2025Article
- Cortical and subcortical mapping of the human allostatic-interoceptive system using 7 Tesla fMRI.Nature neuroscience · 2025Article
- Article
- Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain.Brain structure & function · 2025Article
- Prognostic value of light reflex pupillometry in Alzheimer's disease - a longitudinal cohort study.Alzheimer's research & therapy · 2025Article
- A sensation driven functional MRI study on brain activation during bladder filling in healthy participants.Scientific reports · 2025Article
- Activation of CaMKIICell biology and toxicology · 2025Article
- Terra Incognita - Contributions of the Olivo-Cerebellar System to Autism Spectrum Disorder.Cerebellum (London, England) · 2025Review
- Cortical and subcortical mapping of the allostatic-interoceptive system in the human brain using 7 Tesla fMRI.bioRxiv : the preprint server for biology · 2025Article
- Integrating brainstem and cortical functional architectures.Nature neuroscience · 2024Article
- Atrophy links lower novelty-related locus coeruleus connectivity to cognitive decline in preclinical AD.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Brainstem nuclei play a pivotal role in many functions, such as arousal and motor control. Nevertheless, the connectivity of arousal and motor brainstem nuclei is understudied in living humans due to the limited sensitivity and spatial resolution of conventional imaging, and to the lack of atlases of these deep tiny regions of the brain. For a holistic comprehension of sleep, arousal and associated motor processes, we investigated in 20 healthy subjects the resting-state functional connectivity of 18 arousal and motor brainstem nuclei in living humans. To do so, we used high spatial-resolution 7 Tesla resting-state fMRI, as well as a recently developed in-vivo probabilistic atlas of these nuclei in stereotactic space. Further, we verified the translatability of our brainstem connectome approach to conventional (e.g. 3 Tesla) fMRI. Arousal brainstem nuclei displayed high interconnectivity, as well as connectivity to the thalamus, hypothalamus, basal forebrain and frontal cortex, in line with animal studies and as expected for arousal regions. Motor brainstem nuclei showed expected connectivity to the cerebellum, basal ganglia and motor cortex, as well as high interconnectivity. Comparison of 3 Tesla to 7 Tesla connectivity results indicated good translatability of our brainstem connectome approach to conventional fMRI, especially for cortical and subcortical (non-brainstem) targets and to a lesser extent for brainstem targets. The functional connectome of 18 arousal and motor brainstem nuclei with the rest of the brain might provide a better understanding of arousal, sleep and accompanying motor functions in living humans in health and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.