Evidence map›Paper›PMID 35031451›Full record

ArticleBioorganic & medicinal chemistry letters2022

Antischistosomal tetrahydro-γ-carboline sulfonamides.

Rongguo Ren, Xiaofang Wang, Derek A Leas, Cécile Häberli, Monica Cal, Yuxiang Dong, Marcel Kaiser, Jennifer Keiser, Jonathan L Vennerstrom

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Bridged 1,2,4-Trioxolanes: SnClMolecules (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rongguo RenCollege of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, NE, United States.
Xiaofang WangCollege of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, NE, United States.
Derek A LeasCollege of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, NE, United States.
Cécile HäberliDepartment of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Socinstrasse 57, CH-4002 Basel, Switzerland; University of Basel, CH-4003 Basel, Switzerland.
Monica CalDepartment of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Socinstrasse 57, CH-4002 Basel, Switzerland; University of Basel, CH-4003 Basel, Switzerland.
Yuxiang DongCollege of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, NE, United States.
Marcel KaiserDepartment of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Socinstrasse 57, CH-4002 Basel, Switzerland; University of Basel, CH-4003 Basel, Switzerland.
Jennifer KeiserDepartment of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Socinstrasse 57, CH-4002 Basel, Switzerland; University of Basel, CH-4003 Basel, Switzerland.
Jonathan L VennerstromCollege of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, NE, United States. Electronic address: jvenners@unmc.edu.

Funding

Optimization of Antischistosomal ChemotypesR01AI116723 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI VENNERSTROM, JONATHAN L · 2015 to 2024
$6.2M
NIAID NIH HHS R01 AI116723
6 · The paper itself

Abstract

We discovered tetrahydro-γ-carboline sulfonamides as a new antischistosomal chemotype. The aryl sulfonamide and tetrahydro-γ-carboline substructures were required for high antischistosomal activity. Increasing polarity improved solubility and metabolic stability but decreased antischistosomal activity. We identified two compounds with IC

Indexed as

AnimalsCarbolinesDose-Response Relationship, DrugMolecular StructureSchistosoma mansoniStructure-Activity RelationshipSulfonamidesCarbolinesgamma-carbolineSulfonamidesAntischistosomalSARSulfonamidesTetrahydro-γ-carboline

Identifiers

PMID35031451
PMCPMC8826590

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.