Evidence map›Paper›PMID 35031425›Full record

ReviewGene2022

Calcium selective channel TRPV6: Structure, function, and implications in health and disease.

Vinayak Khattar, Lingyun Wang, Ji-Bin Peng

Open access · greenAbstract readReview
In one paragraph

Review in Gene, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Reevaluating the role of TRPV6 deficiency in human and mouse pancreatitis.American journal of physiology. Gastrointestinal and liver physiology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. TRPV6 channel function is involved in endometrial epithelial cell CaCellular and molecular life sciences : CMLS · 2025
    Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. The Molecular Biology of Placental Transport of Calcium to the Human Foetus.International journal of molecular sciences · 2025
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Vinayak KhattarDivision of Nephrology, Department of Medicine, Nephrology Research and Training Center, Department of Urology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Lingyun WangDivision of Nephrology, Department of Medicine, Nephrology Research and Training Center, Department of Urology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Ji-Bin PengDivision of Nephrology, Department of Medicine, Nephrology Research and Training Center, Department of Urology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: jpeng@uab.edu.
University of Alabama at Birmingham · USPediatric Nephrology of Alabama · US

Funding

The Gene Wiki: Community intelligence applied to gene annotationR01GM089820 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI SU, ANDREW I · 2010 to 2021
$5.2M
Hypercalciuria and TRPV6-mediated Active Calcium Reabsorption in the Proximal TubuleR01DK104924 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PENG, JI-BIN · 2017 to 2021
$1.7M
NIDDK NIH HHS R01 DK104924NIGMS NIH HHS R01 GM089820
6 · The paper itself

Abstract

Calcium-selective channel TRPV6 (Transient Receptor Potential channel family, Vanilloid subfamily member 6) belongs to the TRP family of cation channels and plays critical roles in transcellular calcium (Ca

Indexed as

AnimalsBiophysical PhenomenaChromosome MappingHumansIon Channel GatingModels, MolecularPhylogenyProtein ConformationStructure-Activity RelationshipTissue DistributionTRPV Cation ChannelsTRPV6 channelTRPV Cation ChannelsCalcium absorptionCalcium channelCalmodulinCancerChronic pancreatitisGating mechanismKidney stonesMaternal-fetal transportTranscellular pathwayTransient neonatal hyperparathyroidismTRPV5TRPV6

Identifiers

PMID35031425
PMCPMC8950124
OpenAlexW4205580792

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.