ArticleBrain, behavior, and immunity2022
Lifetime stressor exposure, systemic inflammation during pregnancy, and preterm birth among Black American women.
Article in Brain, behavior, and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prenatal allostatic load and preterm birth: A systematic review.Frontiers in psychology · 2022Pooled it
- An Investigation of Elevated Serum Copper Levels Following Bariatric Surgery.Obesity surgery · 2026Article
- Primary Care Implementation of an Evidence-Based Protocol Addressing Women's Behavioral Health: An Interrupted Time Series Analysis.Journal of general internal medicine · 2026Article
- Validating the stress and adversity inventory for adults (Adult STRAIN) among urban middle-aged and older African Americans.Journal of health psychology · 2026Article
- Superwoman Schema Endorsement and its Association to Perceived Stress During Pregnancy and Birth Outcomes among Non-Hispanic Black American Women.Journal of racial and ethnic health disparities · 2026Article
- Race-based differences in serum biomarkers for cancer-associated cachexia in a diverse cohort of patients with pancreatic ductal adenocarcinoma.Communications medicine · 2025Article
- Climate Change, Racism, and Food Insecurity: Cyclical Impacts of Stressors Exacerbate Health Disparities.Journal of racial and ethnic health disparities · 2025Review
- Maternal plasma extracellular vesicles tsRNA as potential biomarkers for assessing preterm labor risk.BMC pregnancy and childbirth · 2025Article
- Lifetime stressor exposure is related to suicidality in autistic adults: A multinational study.Autism : the international journal of research and practice · 2025Article
- Maternal inflammation during the second trimester of pregnancy with adverse birth outcomes: a prospective cohort study.World journal of pediatrics : WJP · 2025Article
- Is BMI a Useful Indicator of Prenatal Health Among Black American Women?Journal of racial and ethnic health disparities · 2024Article
- Black-white differences in chronic stress exposures to predict preterm birth: interpretable, race/ethnicity-specific machine learning model.BMC pregnancy and childbirth · 2024Article
- The Social Context of Pregnancy, Respectful Maternity Care, Biomarkers of Weathering, and Postpartum Mental Health Inequities: A Scoping Review.International journal of environmental research and public health · 2024Article
- sPDGFRβ and neuroinflammation are associated with AD biomarkers and differ by race: The ASCEND Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Multi-omics approaches in psychoneuroimmunology and health research: Conceptual considerations and methodological recommendations.Brain, behavior, and immunity · 2023Article
- Prematurely delivering mothers show reductions of lachnospiraceae in their gut microbiomes.BMC microbiology · 2023Article
- Managing Pregnancy and Nursing Affecting African American Women with Inflammatory Bowel Disease: Clinical Outcomes and Parenthood.Medical research archives · 2023Article
- The Temporal Relationship Between the Coronavirus Disease 2019 (COVID-19) Pandemic and Preterm Birth.Obstetrics and gynecology · 2023Observational
- Depression screening may not capture significant sources of prenatal stress for Black women.Archives of women's mental health · 2023Article
- Targeting the brain 5-HT7 receptor to prevent hypomyelination in a rodent model of perinatal white matter injuries.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
Corrections and comments
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Authors and funding
9 authors.
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Abstract
Although Black American mothers and infants are at higher risk for morbidity and mortality than their White counterparts, the biological mechanisms underlying these phenomena remain largely unknown. To investigate the role that lifetime stressor exposure, perceived stressor severity, and systemic inflammatory markers might play, we studied how these factors were interrelated in 92 pregnant Black American women. We also compared inflammatory marker levels for women who did versus did not go on to give birth preterm. During the early third trimester, women completed the Stress and Adversity Inventory for Adults to assess the stressors they experienced over their lifetime. Women also provided blood samples for plasma interleukin (IL)-6, IL-8, IL-1β, and tumor necrosis factor (TNF)-α quantification. Preterm births were identified by medical record review. Controlling for relevant covariates, there were significant positive associations between average levels of both overall and acute perceived stressor severity and plasma IL-1β levels. Controlling for perceived stress at assessment and exposure to racial discrimination did not affect these results. Mediation models revealed that exposure to more chronic stressors was related to higher plasma IL-1β levels, as mediated by higher average levels of overall perceived stressor severity. Exposure to fewer acute stressors was related to higher plasma IL-1β levels, as mediated by higher average levels of acute perceived stressor severity. Finally, women who went on to give birth preterm had higher levels of plasma IL-6. These data thus highlight the potential importance of assessing and addressing lifetime stressor exposure among mothers before and during maternal-infant care.
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