Evidence map›Paper›PMID 35031324›Full record

ArticleToxicology and applied pharmacology2022

Arsenic activates STAT3 signaling during the transformation of the human bronchial epithelial cells.

Bandar Almutairy, Yao Fu, Zhuoyue Bi, Wenxuan Zhang, Priya Wadgaonkar, Yiran Qiu, Chitra Thakur, Fei Chen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology and applied pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. miRNAs and arsenic-induced carcinogenesis.Advances in pharmacology (San Diego, Calif.) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Bandar AlmutairyDepartment of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA; College of Pharmacy, Al-Dawadmi Campus, Shaqra University, P.O.Box 11961, Riyadh, Saudi Arabia.
Yao FuStony Brook Cancer Center, Renaissance School of Medicine, Stony Brook University, Lauterbur Drive, Stony Brook, NY 11794, USA.
Zhuoyue BiStony Brook Cancer Center, Renaissance School of Medicine, Stony Brook University, Lauterbur Drive, Stony Brook, NY 11794, USA.
Wenxuan ZhangStony Brook Cancer Center, Renaissance School of Medicine, Stony Brook University, Lauterbur Drive, Stony Brook, NY 11794, USA.
Priya WadgaonkarDepartment of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA.
Yiran QiuStony Brook Cancer Center, Renaissance School of Medicine, Stony Brook University, Lauterbur Drive, Stony Brook, NY 11794, USA.
Chitra ThakurStony Brook Cancer Center, Renaissance School of Medicine, Stony Brook University, Lauterbur Drive, Stony Brook, NY 11794, USA; Department of Pathology, Renaissance School of Medicine, Stony Brook University, 101 Nicolls Road, Stony Brook, NY 11794, USA.
Fei ChenStony Brook Cancer Center, Renaissance School of Medicine, Stony Brook University, Lauterbur Drive, Stony Brook, NY 11794, USA; Department of Pathology, Renaissance School of Medicine, Stony Brook University, 101 Nicolls Road, Stony Brook, NY 11794, USA. Electronic address: Fei.Chen.1@stonybrook.edu.
Stony Brook University · USEugene Applebaum College of Pharmacy and Health Sciences · USWayne State University · US

Funding

Reduced Reactive Oxygen Species and Oxidative Phosphorylation in Arsenic-Induced Cancer Stem CellsR01ES028263 · NIEHS · WAYNE STATE UNIVERSITY · PI CHEN, FEI · 2017 to 2021
$1.9M
Dissecting Nrf2-dependent HIF1a activation mechanism in arsenic-induced cancer stem-like cellsR01ES031822 · NIEHS · WAYNE STATE UNIVERSITY · PI CHEN, FEI · 2021 to 2025
$1.8M
Arsenic-Induced miRNA-199 and mriRNA-214 Deplete Mitochondrial DNA for the Generation of Cancer Stem-Like CellsR01ES028335 · NIEHS · WAYNE STATE UNIVERSITY · PI CHEN, FEI · 2018 to 2022
$1.3M
NIEHS NIH HHS R01 ES028263NIEHS NIH HHS R01 ES028335NIEHS NIH HHS R01 ES031822
6 · The paper itself

Abstract

Arsenic (As

Indexed as

Apoptosis Regulatory ProteinsArsenicBronchiCarcinogenesisCells, CulturedCell Transformation, NeoplasticEpithelial CellsGene Expression Regulation, NeoplasticHumansLung NeoplasmsPhosphorylationReactive Oxygen SpeciesRNA-Binding ProteinsSignal TransductionSTAT3 Transcription FactorApoptosis Regulatory ProteinsArsenicReactive Oxygen SpeciesRNA-Binding ProteinsSTAT3 protein, humanSTAT3 Transcription FactorArsenicmiR-21PDCD4STAT3Transformation

Identifiers

PMID35031324
PMCPMC9056082
OpenAlexW4206462328

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.