Evidence map›Paper›PMID 35031163›Full record

ArticleEuropean urology2022

A Rare Germline HOXB13 Variant Contributes to Risk of Prostate Cancer in Men of African Ancestry.

Burcu F Darst, Raymond Hughley, Aaron Pfennig, Ujani Hazra, Caoqi Fan, Peggy Wan, Xin Sheng, Lucy Xia, Caroline Andrews, Fei Chen and 91 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01221168 (ProGene), which is not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01221168 recruitingnot on this map

ProGene: Etude Genetique et Epidemiologique du Cancer de la Prostate Familial

TypeobservationalSponsorCentre de Recherche sur les Pathologies ProstatiquesRan1996 to 2026Enrolled10,000ConditionsProstate Cancer
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Prostate cancer in Nigeria: a scoping review and meta-analysis of current evidence on process indicators and interventions.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2025
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

101 authors at 20 institutions in 8 countries.

Burcu F DarstCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. Electronic address: bdarst@usc.edu.
Raymond HughleyCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Aaron PfennigSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Ujani HazraSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Caoqi FanCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA.
Peggy WanCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Xin ShengCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lucy XiaCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Caroline AndrewsHarvard TH Chan School of Public Health and Division of Population Sciences, Dana Farber Cancer Institute, Boston, MA, USA.
Fei ChenCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
Zsofia Kote-JaraiThe Institute of Cancer Research, Sutton, London, UK.
Koveela GovindasamiThe Institute of Cancer Research, Sutton, London, UK; Royal Marsden NHS Foundation Trust, London, UK.
Jeannette T BensenDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sue A InglesCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
Benjamin A RybickiDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.
Barbara NemesureDepartment of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA.
Esther M JohnDepartment of Epidemiology & Population Health and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
Jay H FowkeDivision of Epidemiology, Department of Preventive Medicine, The University of Tennessee Health Science Center, TN, USA.
Chad D HuffDepartment of Epidemiology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Sara S StromDepartment of Epidemiology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
William B IsaacsJames Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institution, Baltimore, MD, USA.
Jong Y ParkDepartment of Cancer Epidemiology, Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Elaine A OstranderCancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Patrick C WalshJames Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institution, Baltimore, MD, USA.
John CarptenDepartment of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Thomas A SellersDepartment of Cancer Epidemiology, Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Kosj YamoahDepartment of Radiation Oncology and Cancer Epidemiology, Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Adam B MurphyDepartment of Urology, Northwestern University, Chicago, IL, USA.
Maureen SandersonDepartment of Family and Community Medicine, Meharry Medical College, Nashville, TN, USA.
Dana C CrawfordCleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Susan M GapsturEpidemiology Research Program, American Cancer Society, Atlanta, GA, USA.
William S BushCleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Melinda C AldrichDepartment of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Olivier CussenotCeRePP & Sorbonne Universite, GRC n° 5, AP-HP, Tenon Hospital, Paris, France.
Gyorgy PetrovicsCenter for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Jennifer CullenCenter for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Christine Neslund-DudasDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.
Rick A KittlesDepartment of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
Jianfeng XuProgram for Personalized Cancer Care and Department of Surgery, NorthShore University HealthSystem, Evanston, IL, USA.
Mariana C SternCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
Anand P ChokkalingamSchool of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Luc MultignerUniv Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) -UMR_S 1085, Rennes, France.
Marie-Elise ParentCentre Armand-Frappier Santé Biotechnologie, Institut national de la recherche scientifique, University of Quebec, Laval, Quebec, Canada.
Florence MenegauxUniversité Paris-Saclay, Université Paris-Sud, CESP (Center for Research in Epidemiology and Population Health), Inserm, Team Cancer-Environment, Villejuif, France.
Geraldine Cancel-TassinCeRePP & Sorbonne Universite, GRC n° 5, AP-HP, Tenon Hospital, Paris, France.
Adam S KibelDivision of Urology, Brigham and Women's Hospital/Dana-Farber Cancer Institute, Boston, MA, USA; Washington University, St. Louis, MO, USA.
Eric A KleinGlickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.
Phyllis J GoodmanSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Janet L StanfordDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Bettina F DrakeDepartment of Surgery, Division of Public Health Sciences, Washington University School of Medicine, St. Louis, MO, USA.
Jennifer J HuSylvester Comprehensive Cancer Center and Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Peter E ClarkAtrium Health/Levine Cancer Institute, Charlotte, NC, USA.
Pascal BlanchetCHU de Guadeloupe, Univ Antilles, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) -UMR_S 1085, Rennes, France.
Graham CaseyCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Anselm J M HennisDepartment of Preventive Medicine, Stony Brook University, Stony Brook, NY, USA; George Alleyne Chronic Disease Research Centre and Faculty of Medical Sciences, The University of the West Indies, Bridgetown, Barbados.
Alexander LubwamaSchool of Public Health, Makerere University College of Health Sciences, Kampala, Uganda.
Ian M ThompsonCHRISTUS Santa Rosa Health System and The University of Texas Health Science Center, San Antonio, TX, USA.
Robin J LeachDepartment of Cell Systems and Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Susan M GundellCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Loreall PoolerCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
James L MohlerLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Urology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Elizabeth T H FonthamSchool of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Gary J SmithDepartment of Urology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Jack A TaylorEpigenetic and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA; Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Laurent BrureauCHU de Guadeloupe, Univ Antilles, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) -UMR_S 1085, Rennes, France.
William J BlotDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Richard BiritwumKorle Bu Teaching Hospital, Accra, Ghana.
Evelyn TayKorle Bu Teaching Hospital, Accra, Ghana.
Ann TrueloveWestat, Rockville, MD, USA.
Shelley NiwaWestat, Rockville, MD, USA.
Yao TetteyKorle Bu Teaching Hospital, Accra, Ghana; University of Ghana Medical School, Accra, Ghana.
Rohit VarmaSouthern California Eye Institute, CHA Hollywood Presbyterian Medical Center, Los Angeles, CA, USA.
Roberta McKean-CowdinCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
Mina TorresSouthern California Eye Institute, CHA Hollywood Presbyterian Medical Center, Los Angeles, CA, USA.
Mohamed JallohHôpital Général Idrissa Pouye, Dakar, Senegal.
Serigne Magueye GueyeHôpital Général Idrissa Pouye, Dakar, Senegal.
Lamine NiangHôpital Général Idrissa Pouye, Dakar, Senegal.
Olufemi OgunbiyiCollege of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria.
Michael Oladimeji IdowuCollege of Medicine, University of Ibadan, Ibadan, Nigeria.
Olufemi PopoolaCollege of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria.
Akindele O AdebiyiCollege of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria.
Oseremen I Aisuodionoe-ShadrachCollege of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Center, Abuja, Nigeria.
Maxwell NwegbuCollege of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Center, Abuja, Nigeria.
Ben Adusei37 Military Hospital, Accra, Ghana.
Sunny Mante37 Military Hospital, Accra, Ghana.
Afua Darkwa-AbrahamsKorle Bu Teaching Hospital, Accra, Ghana.
Edward D YeboahKorle Bu Teaching Hospital, Accra, Ghana; University of Ghana Medical School, Accra, Ghana.
James E MensahKorle Bu Teaching Hospital, Accra, Ghana.
Andrew Anthony AdjeiKorle Bu Teaching Hospital, Accra, Ghana.
Halimatou DiopLaboratoires Bacteriologie et Virologie, Hôpital Aristide Le Dantec, Dakar, Senegal.
Michael B CookDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
Stephen WatyaSchool of Public Health, Makerere University College of Health Sciences, Kampala, Uganda; Uro Care, Kampala, Uganda.
Rosalind A EelesThe Institute of Cancer Research, Sutton, London, UK; Royal Marsden NHS Foundation Trust, London, UK.
Charleston W K ChiangCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA.
Joseph LachanceSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Timothy R RebbeckHarvard TH Chan School of Public Health and Division of Population Sciences, Dana Farber Cancer Institute, Boston, MA, USA.
David V ContiCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
Christopher A HaimanCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. Electronic address: haiman@usc.edu.
University of Southern California · USFred Hutch Cancer Center · USCase Western Reserve University · USNational Institutes of Health · USDana-Farber Cancer Institute · USGeorgia Institute of Technology · USUniversity of Virginia · USÉcole des Hautes Études en Santé Publique · FRHenry Ford Hospital · USHôpital Principal de Dakar · SNInserm · FRInstitut de Recherche en Santé, Environnement et Travail · FRInstitute of Cancer Research · GBInstitut National de la Recherche Scientifique · CAJohns Hopkins Hospital · USLevine Cancer Institute · USLouisiana State University Health Sciences Center New Orleans · USMakerere University · UGNational Cancer Institute · USNational Human Genome Research Institute · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
SWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6M
Finding Genes for Human Prostate CancerZIAHG200325 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI OSTRANDER, ELAINE · 2009 to 2021
$17.7M
Research on Prostate Cancer in Men of African Ancestry: Defining the Roles of Genetics, Immunity and Stress (RESPOND)U19CA214253 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAIMAN, CHRISTOPHER ALAN · 2018 to 2023
$16.8M
Epidemiological and Clinical Translational Studies Post Genome-Wide AssociationU19CA148537 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EASTON, DOUGLAS FREDERICK, EELES, ROSALIND · 2010 to 2014
$10.4M
Genetic Susceptibility And The Environment In Cancer RiskZIAES049033 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI TAYLOR, JACK A · 2009 to 2022
$7.7M
PCPT and SELECT Cohorts: Core Infrastructure Support for Cancer ResearchU01CA182883 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TANGEN, CATHERINE M., THOMPSON, IAN M. · 2019 to 2023
$5.4M
Leveraging Prospective Cancer Epidemiology Cohorts and Novel Methods to Improve Polygenic Risk ScoresU01CA261339 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fei Chen, David V Conti · 2021 to 2026
$5.2M
PCPT and SELECT cohorts: Core Infrastructure Support for Cancer Research UM1CA182883 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TANGEN, CATHERINE M., THOMPSON, IAN M. · 2013 to 2017
$5.2M
Genome-wide sequencing of prostate cancer in men of African ancestryR01CA165862 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAIMAN, CHRISTOPHER ALAN, REICH, DAVID E · 2012 to 2016
$3.1M
Multiethnic GWAS and TWAS to Inform Risk Prediction for Prostate CancerU01CA257328 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CONTI, DAVID V, HAIMAN, CHRISTOPHER ALAN · 2021 to 2025
$3.1M
An evolutionary framework to elucidate and interpret the genetic architecture of complex traits in diverse populations - diversity supplementR35GM142783 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHIANG, CHARLESTON · 2021 to 2025
$2.2M
NCI NIH HHS K99 CA246063NCI NIH HHS P30 CA016672NCI NIH HHS R00 CA246063NCI NIH HHS R01 CA165862NCI NIH HHS T32 CA229110NCI NIH HHS U01 CA182883NCI NIH HHS U01 CA257328NCI NIH HHS U01 CA261339NCI NIH HHS U19 CA148537NCI NIH HHS U19 CA214253NCI NIH HHS UG1 CA189974NCI NIH HHS UM1 CA182883NIGMS NIH HHS R35 GM133727NIGMS NIH HHS R35 GM142783
6 · The paper itself

Abstract

A rare African ancestry-specific germline deletion variant in HOXB13 (X285K, rs77179853) was recently reported in Martinican men with early-onset prostate cancer. Given the role of HOXB13 germline variation in prostate cancer, we investigated the association between HOXB13 X285K and prostate cancer risk in a large sample of 22 361 African ancestry men, including 11 688 prostate cancer cases. The risk allele was present only in men of West African ancestry, with an allele frequency in men that ranged from 0.40% in Ghana and 0.31% in Nigeria to 0% in Uganda and South Africa, with a range of frequencies in men with admixed African ancestry from North America and Europe (0-0.26%). HOXB13 X285K was associated with 2.4-fold increased odds of prostate cancer (95% confidence interval [CI] = 1.5-3.9, p = 2 × 10

Indexed as

Early Detection of CancerProstatic NeoplasmsCase-Control StudiesGenetic Predisposition to DiseaseGerm CellsGerm-Line MutationHomeodomain ProteinsHumansMaleProstate-Specific AntigenHomeodomain ProteinsHOXB13 protein, humanProstate-Specific AntigenAfrican ancestryAllelic ageGeneticsHealth disparitiesHOXB13Prostate cancerRare genetic variants

Identifiers

PMID35031163
PMCPMC9018520
OpenAlexW4206592801

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.