Evidence map›Paper›PMID 35031121›Full record

ArticleJournal of the neurological sciences2022

Demographic and social determinants of cognitive dysfunction following hospitalization for COVID-19.

Eduard Valdes, Benjamin Fuchs, Chris Morrison, Leigh Charvet, Ariane Lewis, Sujata Thawani, Laura Balcer, Steven L Galetta, Thomas Wisniewski, Jennifer A Frontera

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the neurological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Neurocognitive Impairment in Long COVID: A Systematic Review.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025
    Pooled it
  2. COVID-19 associated cognitive impairment: A systematic review.Cortex; a journal devoted to the study of the nervous system and behavior · 2022
    Pooled it
  3. Article
  4. Family stress model pathways to cognitive function in older adulthood.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2026
    Article
  5. Article
  6. Cognitive impairment in long-COVID: frequency, trajectories and risk factors in a cohort study from Italy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  7. Article
  8. Observational
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Neurophenotypes of COVID-19: Risk factors and recovery outcomes.Brain, behavior, & immunity - health · 2023
    Article
  17. Observational
  18. Article
  19. Article
  20. Neuropsychiatric aspects of long COVID: A comprehensive review.Psychiatry and clinical neurosciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Eduard ValdesDepartment of Neurology, New York University Grossman School of Medicine, New York, NY, USA.
Benjamin FuchsDepartment of Neurology, New York University Grossman School of Medicine, New York, NY, USA.
Chris MorrisonDepartment of Neurology, New York University Grossman School of Medicine, New York, NY, USA.
Leigh CharvetDepartment of Neurology, New York University Grossman School of Medicine, New York, NY, USA.
Ariane LewisDepartment of Neurology, New York University Grossman School of Medicine, New York, NY, USA.
Sujata ThawaniDepartment of Neurology, New York University Grossman School of Medicine, New York, NY, USA.
Laura BalcerDepartment of Neurology, New York University Grossman School of Medicine, New York, NY, USA.
Steven L GalettaDepartment of Neurology, New York University Grossman School of Medicine, New York, NY, USA.
Thomas WisniewskiDepartment of Neurology, New York University Grossman School of Medicine, New York, NY, USA.
Jennifer A FronteraDepartment of Neurology, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: jennifer.frontera@nyulangone.org.
New York University · US

Funding

Research Education ComponentP30AG066512 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Mary Sherman Mittelman · 2020 to 2026
$28.4M
Transgenic/Behavior CoreP01AG060882 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WISNIEWSKI, THOMAS M · 2020 to 2024
$12.0M
NIA NIH HHS P01 AG060882NIA NIH HHS P30 AG066512
6 · The paper itself

Abstract

backgroundPersistent cognitive symptoms have been reported following COVID-19 hospitalization. We investigated the relationship between demographics, social determinants of health (SDOH) and cognitive outcomes 6-months after hospitalization for COVID-19.

methodsWe analyzed 6-month follow-up data collected from a multi-center, prospective study of hospitalized COVID-19 patients. Demographic and SDOH variables (age, race/ethnicity, education, employment, health insurance status, median income, primary language, living arrangements, and pre-COVID disability) were compared between patients with normal versus abnormal telephone Montreal Cognitive Assessments (t-MOCA; scores<18/22). Multivariable logistic regression models were constructed to evaluate predictors of t-MoCA.

resultsOf 382 patients available for 6-month follow-up, 215 (56%) completed the t-MoCA (n = 109/215 [51%] had normal and n = 106/215 [49%] abnormal results). 14/215 (7%) patients had a prior history of dementia/cognitive impairment. Significant univariate predictors of abnormal t-MoCA included older age, ≤12 years of education, unemployment pre-COVID, Black race, and a pre-COVID history of cognitive impairment (all p < 0.05). In multivariable analyses, education ≤12 years (adjusted OR 5.21, 95%CI 2.25-12.09), Black race (aOR 5.54, 95%CI 2.25-13.66), and the interaction of baseline functional status and unemployment prior to hospitalization (aOR 3.98, 95%CI 1.23-12.92) were significantly associated with abnormal t-MoCA scores after adjusting for age, history of dementia, language, neurological complications, income and discharge disposition.

conclusionsFewer years of education, Black race and unemployment with baseline disability were associated with abnormal t-MoCA scores 6-months post-hospitalization for COVID-19. These associations may be due to undiagnosed baseline cognitive dysfunction, implicit biases of the t-MoCA, other unmeasured SDOH or biological effects of SARS-CoV-2.

Indexed as

Cognitive DysfunctionCOVID-19DementiaHospitalizationHumansProspective StudiesSARS-CoV-2Social Determinants of HealthBrain fogCognitionCognitiveCOVID-19Long-COVIDLong-haulerMemoryMOCAPost-acute sequelae of COVIDSARS-CoV-2

Identifiers

PMID35031121
PMCPMC8739793
OpenAlexW4206118053

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.