Evidence map›Paper›PMID 35030972›Full record

ArticleBioengineered2022

Propofol inhibits oxidative stress injury through the glycogen synthase kinase 3 beta/nuclear factor erythroid 2-related factor 2/heme oxygenase-1 signaling pathway.

Ziyin Zhang, BaoFeng Yan, Yuguo Li, Shuo Yang, Jinfeng Li

RetractedOpen access · goldAbstract readVideo-Audio MediaRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Ziyin ZhangDepartment of Anesthesiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, China.
BaoFeng YanDepartment of Anesthesiology, Fifth Medical Center of Chinese Pla General Hospital, Beijing, China.
Yuguo LiDepartment of Anesthesiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, China.
Shuo YangDepartment of Medical Administration, The Eleventh People's Hospital of Guangzhou, Guangdong, China.
Jinfeng LiDepartment of Anesthesiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, China.
Guangzhou University of Chinese Medicine · CNChinese PLA General Hospital · CNFirst Affiliated Hospital of Guangzhou University of Chinese Medicine · CNTwelfth Guangzhou City People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress is the main cause of ischemia/reperfusion injury. Propofol is a commonly used intravenous hypnotic anesthetic agent with antioxidant properties. In this study, we aimed to elucidate the protective effects of propofol on H

Indexed as

AnimalsCell LineGlycogen Synthase Kinase 3 betaHeme Oxygenase (Decyclizing)MaleMyocardial Reperfusion InjuryNF-E2-Related Factor 2Oxidative StressPropofolRatsRats, Sprague-DawleySignal TransductionGlycogen Synthase Kinase 3 betaGsk3b protein, ratHeme Oxygenase (Decyclizing)Hmox1 protein, ratNfe2l2 protein, ratNF-E2-Related Factor 2Propofolcardiomyocyte injuryGSK3β-Nrf2/HO-1myocardial ischemic reperfusion injury (MIRI)oxidative stressPropofol

Identifiers

PMID35030972
PMCPMC8805835
OpenAlexW4206282213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.