Evidence map›Paper›PMID 35030471›Full record

ArticleJournal of the mechanical behavior of biomedical materials2022

Natural cardiac regeneration conserves native biaxial left ventricular biomechanics after myocardial infarction in neonatal rats.

Hanjay Wang, Andrew Wisneski, Annabel M Imbrie-Moore, Michael J Paulsen, Zhongjie Wang, Yue Xuan, Hector Lopez Hernandez, Camille E Hironaka, Haley J Lucian, Hye Sook Shin and 12 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the mechanical behavior of biomedical materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 1 country.

Hanjay WangDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.
Andrew WisneskiDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Annabel M Imbrie-MooreDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA; Department of Mechanical Engineering, Stanford University, Stanford, CA, USA.
Michael J PaulsenDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Zhongjie WangDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Yue XuanDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Hector Lopez HernandezDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
Camille E HironakaDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Haley J LucianDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Hye Sook ShinDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Shreya AnilkumarDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Akshara D ThakoreDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Justin M FarryDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Anahita EskandariDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Kiah M WilliamsDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Frederick GradyDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Matthew A WuDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Jinsuh JungDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Lyndsay M StapletonDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA.
Amanda N SteeleDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA.
Yuanjia ZhuDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA.
Y Joseph WooDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA. Electronic address: joswoo@stanford.edu.
Stanford University · USUniversity of California, San Francisco · USCardiovascular Institute of the South · USStanford Medicine · US

Funding

ANGIOGENIC TISSUE ENGINEERING TO LIMIT POST-INFARCTION VENTRICULAR REMODELINGR01HL089315 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WOO, Y JOSEPH · 2008 to 2023
$6.4M
American Heart Association-American Stroke Association 17POST33410497American Heart Association-American Stroke Association 18POST33990223NHLBI NIH HHS R01 HL089315
6 · The paper itself

Abstract

After myocardial infarction (MI), adult mammals exhibit scar formation, adverse left ventricular (LV) remodeling, LV stiffening, and impaired contractility, ultimately resulting in heart failure. Neonatal mammals, however, are capable of natural heart regeneration after MI. We hypothesized that neonatal cardiac regeneration conserves native biaxial LV mechanics after MI. Wistar rat neonates (1 day old, n = 46) and adults (8-10 weeks old, n = 20) underwent sham surgery or permanent left anterior descending coronary artery ligation. At 6 weeks after neonatal MI, Masson's trichrome staining revealed negligible fibrosis. Echocardiography for the neonatal MI (n = 15) and sham rats (n = 14) revealed no differences in LV wall thickness or chamber diameter, and both groups had normal ejection fraction (72.7% vs 77.5%, respectively, p = 0.1946). Biaxial tensile testing revealed similar stress-strain curves along both the circumferential and longitudinal axes across a full range of physiologic stresses and strains. The circumferential modulus (267.9 kPa vs 274.2 kPa, p = 0.7847), longitudinal modulus (269.3 kPa vs 277.1 kPa, p = 0.7435), and maximum shear stress (3.30 kPa vs 3.95 kPa, p = 0.5418) did not differ significantly between the neonatal MI and sham groups, respectively. In contrast, transmural scars were observed at 4 weeks after adult MI. Adult MI hearts (n = 7) exhibited profound LV wall thinning (p < 0.0001), chamber dilation (p = 0.0246), and LV dysfunction (ejection fraction 45.4% vs 79.7%, p < 0.0001) compared to adult sham hearts (n = 7). Adult MI hearts were significantly stiffer than adult sham hearts in both the circumferential (321.5 kPa vs 180.0 kPa, p = 0.0111) and longitudinal axes (315.4 kPa vs 172.3 kPa, p = 0.0173), and also exhibited greater maximum shear stress (14.87 kPa vs 3.23 kPa, p = 0.0162). Our study is the first to show that native biaxial LV mechanics are conserved after neonatal heart regeneration following MI, thus adding biomechanical support for the therapeutic potential of cardiac regeneration in the treatment of ischemic heart disease.

Indexed as

Myocardial InfarctionAnimalsAnimals, NewbornBiomechanical PhenomenaCicatrixDisease Models, AnimalMyocardiumRatsRats, WistarVentricular RemodelingBiaxial tensionHeartMyocardial infarctionNeonateRegenerationVentricular remodeling

Identifiers

PMID35030471
PMCPMC8899021
OpenAlexW4205392693

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.