Evidence map›Paper›PMID 35030424›Full record

ArticleDNA repair2022

A combination of direct reversion and nucleotide excision repair counters the mutagenic effects of DNA carboxymethylation.

Claudia M N Aloisi, Nora A Escher, Hyun Suk Kim, Susanne M Geisen, Gabriele A Fontana, Jung-Eun Yeo, Orlando D Schärer, Shana J Sturla

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in DNA repair, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Frequent Detection of Abasic Sites andChemical research in toxicology · 2026
    Article
  2. Review
  3. DNA Alkylation Damage by Nitrosamines and Relevant DNA Repair Pathways.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Claudia M N AloisiDepartment of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland.
Nora A EscherDepartment of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland.
Hyun Suk KimCenter for Genomic Integrity, Institute for Basic Science (IBS), Ulsan 44919, Republic of Korea.
Susanne M GeisenDepartment of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland.
Gabriele A FontanaDepartment of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland.
Jung-Eun YeoCenter for Genomic Integrity, Institute for Basic Science (IBS), Ulsan 44919, Republic of Korea; Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.
Orlando D SchärerCenter for Genomic Integrity, Institute for Basic Science (IBS), Ulsan 44919, Republic of Korea; Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea. Electronic address: orlando.scharer@ibs.re.kr.
Shana J SturlaDepartment of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland. Electronic address: sturlas@ethz.ch.

Funding

Transcription-Coupled & Replication-Associated Excision RepairP01CA092584 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI John A. Tainer · 2001 to 2026
$89.6M
The XPA scaffold protein in Nucleotide Excision RepairR01CA218315 · NCI · VANDERBILT UNIVERSITY · PI WALTER J. CHAZIN · 2018 to 2026
$3.4M
European Research Council 260341NCI NIH HHS P01 CA092584NCI NIH HHS R01 CA218315
6 · The paper itself

Abstract

Distinct cellular DNA damage repair pathways maintain the structural integrity of DNA and protect it from the mutagenic effects of genotoxic exposures and processes. The occurrence of O

Indexed as

DNA RepairMutagensDNADNA AdductsDNA DamageMutagenesisO(6)-Methylguanine-DNA MethyltransferaseDNADNA AdductsMutagensO(6)-Methylguanine-DNA MethyltransferaseAzaserineDNA repairMutagenesisNucleotide excision repairO(6)-carboxymethylguanineO(6)-methylguanine-DNA methyltransferase

Identifiers

PMID35030424
PMCPMC9232693

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.