ArticleArtificial organs2022
The effect of blood viscosity on shear-induced hemolysis using a magnetically levitated shearing device.
Article in Artificial organs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- From Early Models to Emerging Trends: The Evolution of Computational Hemolysis Prediction.Annals of biomedical engineering · 2026Review
- Micro Blood Flow-Resolved Rheometry.Micromachines · 2026Article
- In Vitro Comparison of Device-Induced Hemolysis, Platelet Defects, and von Willebrand Factor Degradation Between the HeartMate 2 and HeartMate 3 Pumps.Artificial organs · 2025Article
- Hemoglobin is associated with cardiotoxicity in melanoma patients without anemia receiving immune checkpoint inhibitor therapy.International journal of cardiology. Heart & vasculature · 2025Article
- Mechanical Stimulation of Red Blood Cells Aging: Focusing on the Microfluidics Application.Micromachines · 2025Review
- Fluid-structure interaction in a follow-up study of arterio-venous fistula maturation.Scientific reports · 2024Article
- The dynamics of red blood cells traversing slits of mechanical heart valves under high shear.Biophysical journal · 2024Article
- Empirical and Computational Evaluation of Hemolysis in a Microfluidic Extracorporeal Membrane Oxygenator Prototype.Micromachines · 2024Article
- Turbulence in surgical suction heads as detected by MRI.The journal of extra-corporeal technology · 2023Article
- Perfuse and Reuse: A Low-Cost Three-Dimensional-Printed Perfusion Bioreactor for Tissue Engineering.Tissue engineering. Part C, Methods · 2022Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
introductionBlood contacting medical devices, including rotary blood pumps, can cause shear-induced blood damage that may lead to adverse effects in patients. Due in part to an inadequate understanding of how cell-scale fluid mechanics impact red blood cell membrane deformation and damage, there is currently not a uniformly accepted engineering model for predicting blood damage caused by complex flow fields within ventricular assist devices (VADs).
methodsWe empirically investigated hemolysis in a magnetically levitated axial Couette flow device typical of a rotary VAD. The device is able to accurately control the shear rate and exposure time experienced by blood and to minimize the effects of other uncharacterized stresses. Using this device, we explored the effects of both hematocrit and plasma viscosity on shear-induced hemolysis to characterize blood damage based on the viscosity-independent shear rate, rather than on shear stress.
resultsOver a shear rate range of 20 000 - 80 000 1/s, the Index of Hemolysis (IH) was found to be dependent upon and well-predicted by the shear rate alone. IH was independent of hematocrit, bulk viscosity, or the suspension media viscosity and less correlated to shear stress (MSE = 0.46-0.75) than to shear rate (MSE = 0.06-0.09).
conclusionThis study recommends that future investigations of shear-induced blood damage report findings with respect to the viscosity-neutral term of shear rate, in addition to the bulk whole blood viscosity measured at an appropriate shear rate relevant to the flow conditions of the device.
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