ArticlePloS one2022
Evidence of pyrethroid resistance in Anopheles amharicus and Anopheles arabiensis from Arjo-Didessa irrigation scheme, Ethiopia.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed.
- "Target species complex" concept: Strengthening environmental risk assessment of engineered gene drives.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Spatial and temporal signatures of genomic insecticide resistance in the Anopheles arabiensis mosquito malaria vector from Ethiopia.Research square · 2026Article
- Anopheles larval ecology and physicochemical characterization of larval habitats in Dire Dawa: an area colonized by Anopheles stephensi in Eastern Ethiopia.Research square · 2026Article
- Analysis of a seven-year trend in malaria prevalence at Pawe General Hospital, Northwestern Ethiopia: a retrospective cross-sectional study.BMC infectious diseases · 2026Article
- Heterogeneity of malaria transmission in urban settings in Ethiopia: A seroprevalence and risk factor analysis.PloS one · 2026Article
- Lysinibacillus sphaericus exposure impedes Anopheles dirus's oviposition via downregulating vitellogenin.Parasites & vectors · 2025Article
- Challenges to Malaria Elimination in Ethiopia by 2030: A Review.Journal of tropical medicine · 2025Review
- Larval source management in Ethiopia: modelling to assess its effectiveness in curbing malaria surge in dire Dawa and Batu Towns.Malaria journal · 2024Article
- Knowledge and practices of parents of school age children towards Helminthiasis and malaria in northwestern Ethiopia.BMC public health · 2024Article
- Higher outdoor mosquito density and Plasmodium infection rates in and around malaria index case households in low transmission settings of Ethiopia: Implications for vector control.Parasites & vectors · 2024Article
- Asymptomatic and submicroscopic malaria infections in sugar cane and rice development areas of Ethiopia.Malaria journal · 2023Article
- Impact of Environmental Modifications on the Ecology, Epidemiology, and Pathogenesis of Plasmodium falciparum and Plasmodium vivax Malaria in East Africa.The American journal of tropical medicine and hygiene · 2022Article
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Abstract
backgroundIndoor residual spraying and insecticide-treated nets are among the key malaria control intervention tools. However, their efficacy is declining due to the development and spread of insecticide resistant vectors. In Ethiopia, several studies reported resistance of An. arabiensis to multiple insecticide classes. However, such data is scarce in irrigated areas of the country where insecticides, pesticides and herbicides are intensively used. Susceptibility of An. gambiae s.l. to existing and new insecticides and resistance mechanisms were assessed in Arjo-Didessa sugarcane plantation area, southwestern Ethiopia.
methodsAdult An. gambiae s.l. reared from larval/pupal collections of Arjo-Didessa sugarcane irrigation area and its surrounding were tested for their susceptibility to selected insecticides. Randomly selected An. gambiae s.l. (dead and survived) samples were identified to species using species-specific polymerase chain reaction (PCR) and were further analyzed for the presence of knockdown resistance (kdr) alleles using allele-specific PCR.
resultsAmong the 214 An. gambiae s.l. samples analyzed by PCR, 89% (n = 190) were An. amharicus and 9% (n = 20) were An. arabiensis. Mortality rates of the An. gambiae s.l. exposed to deltamethrin and alphacypermethrin were 85% and 86.8%, respectively. On the other hand, mortalities against pirmiphos-methyl, bendiocarb, propoxur and clothianidin were 100%, 99%, 100% and 100%, respectively. Of those sub-samples (An. amharicus and An. arabiensis) examined for presence of kdr gene, none of them were found to carry the L1014F (West African) allelic mutation.
conclusionAnopheles amharicus and An. arabiensis from Arjo-Didessa sugarcane irrigation area were resistant to pyrethroids which might be synergized by extensive use of agricultural chemicals. Occurrence of pyrethroid resistant malaria vectors could challenge the ongoing malaria control and elimination program in the area unless resistance management strategies are implemented. Given the resistance of An. amharicus to pyrethroids, its behavior and vectorial capacity should be further investigated.
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