Evidence map›Paper›PMID 35030035›Full record

ArticleScience immunology2022

FoxP3 associates with enhancer-promoter loops to regulate T

Ricardo N Ramirez, Kaitavjeet Chowdhary, Juliette Leon, Diane Mathis, Christophe Benoist

Abstract read
In one paragraph

Article in Science immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. ELF5-Mediated Enhancer-Promoter Interaction Regulates LALBA Expression in Ovine Mammary Gland.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. FOXP-stabilization of thebioRxiv : the preprint server for biology · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Dynamics and variegation in the Treg response to Interleukin-2.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ricardo N RamirezDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-1259-5406
Kaitavjeet ChowdharyDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-9595-3706
Juliette LeonDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-5314-8154
Diane MathisDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-6110-4626
Christophe BenoistDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-1172-6555

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Treg cell diversity and homeostatic controlR01AI150686 · NIAID · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O. · 2020 to 2024
$2.6M
Specification of Treg cells: FOXP3 functional facetsR01AI116834 · NIAID · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O. · 2015 to 2019
$2.3M
NIAID NIH HHS R01 AI116834NIAID NIH HHS R01 AI150686NIGMS NIH HHS T32 GM007753
6 · The paper itself

Abstract

Gene expression programs are specified by higher-order chromatin structure and enhancer-promoter loops (EPLs). T regulatory cell (T

Indexed as

AnimalsForkhead Transcription FactorsGene Expression RegulationMiceMice, Inbred C57BLMice, TransgenicPromoter Regions, GeneticT-Lymphocytes, RegulatoryForkhead Transcription FactorsFoxp3 protein, mouse

Identifiers

PMID35030035
PMCPMC9059705

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.