Evidence map›Paper›PMID 35030034›Full record

ArticleScience immunology2022

A subset of follicular helper-like MAIT cells can provide B cell help and support antibody production in the mucosa.

Owen Jensen, Shubhanshi Trivedi, Jeremy D Meier, Keke C Fairfax, J Scott Hale, Daniel T Leung

Abstract read
In one paragraph

Article in Science immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. C-X-C chemokine receptor type 5World journal of gastroenterology · 2025
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  12. Article
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  16. Human MAIT cell response profiles biased toward IL-17 or IL-10 are distinct effector states directed by the cytokine milieu.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Owen JensenDivision of Infectious Diseases, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.ORCID 0000-0002-6670-4743
Shubhanshi TrivediDivision of Infectious Diseases, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.ORCID 0000-0001-6891-2290
Jeremy D MeierDivision of Otolaryngology-Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA.
Keke C FairfaxDivision of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT ,USA.ORCID 0000-0002-8382-2960
J Scott HaleDivision of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT ,USA.ORCID 0000-0003-4318-8472
Daniel T LeungDivision of Infectious Diseases, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.ORCID 0000-0001-8401-0801

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI KATHARINE S ULLMAN · 1986 to 2026
$72.6M
Mucosal associated invariant T (MAIT) cells in Vibrio cholerae infection and vaccinationR01AI130378 · NIAID · UNIVERSITY OF UTAH · PI LEUNG, DANIEL TED · 2017 to 2021
$1.8M
Cross-disciplinary Training in Immunology, Inflammation and Infectious DiseaseT32AI138945 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Tracey Jane Lamb, Matthew A Williams · 2018 to 2026
$1.6M
NCI NIH HHS P30 CA042014NIAID NIH HHS R01 AI130378NIAID NIH HHS T32 AI138945
6 · The paper itself

Abstract

Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes that aid in protection against bacterial pathogens at mucosal surfaces through the release of inflammatory cytokines and cytotoxic molecules. Recent evidence suggests that MAIT cells can also provide B cell help. In this study, we describe a population of CXCR5

Indexed as

AdolescentAdultAnimalsAntibodiesAntibody FormationB-LymphocytesChildChild, PreschoolFemaleHumansMaleMiceMice, Inbred C57BLMice, TransgenicMucosal-Associated Invariant T CellsMucous MembraneAntibodies

Identifiers

PMID35030034
PMCPMC9001248

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.