Investigation of the different parameters contributing to bubble sticking inside physiological bifurcations.

Gas embolotherapy (GE) is a developing medical method which can be utilized either as an autonomous therapeutic method to treat vascularized solid tumors, or it can be combined with other medical procedures-such as high-intensity focused ultrasound-to improve their efficiency. This paper is dedicated to investigating the different parameters which influence bubble lodging inside human vasculature via 2D-modeling of bubble dynamics in arteries' and arterioles' bifurcations which are potential sticking positions. Values used in the simulations are in accordance with the non-dimensional physiological numbers. It is found out that inlet pressure plays a decisive role in bubble lodging; the lower the value, the higher the possibility of bubble sticking. On the other hand, gravity has a counteracting effect on bubble lodging in arteries, but not on arterioles. The initial length of the bubble is not a determining factor in sticking behavior, even though it affects the flow rate behavior. Surface tension, another critical factor, has a semi-linear impact on bubble resisting power; lowering the surface tension will reduce bubble resistance to the flow, diminishing the possibility of bubble lodging. Finally, it is shown that lower values for the static contact angle impose higher resistance to the flow.