ArticleEuropean radiology2022
Functional MRI evidence for primary motor cortex plasticity contributes to the disease's severity and prognosis of cervical spondylotic myelopathy patients.
Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Beyond the aging spine - a systematic review of functional changes in the human brain in cervical spondylotic myelopathy.GeroScience · 2024Pooled it
- Brain MRI changes in degenerative cervical myelopathy: a systematic review.EBioMedicine · 2024Pooled it
- Abnormalities of brain structure and function in cervical spondylosis: a multi-modal voxel-based meta-analysis.Frontiers in neuroscience · 2024Pooled it
- Meta-analysis of resting-state fMRI in cervical spondylosis patients using AES-SDM.Frontiers in neurology · 2024Pooled it
- Investigation of cerebellar structure and static and dynamic functional connectivity in cervical spondylotic myelopathy patients.Neuroradiology · 2026Article
- Increased cervical spinal cord signal intensity corresponds to specific cerebellar and cerebral functional changes in degenerative cervical myelopathy patients.Scientific reports · 2026Article
- Integrative multimodal framework combining undercarboxylated osteocalcin and medial prefrontal cortex morphometry for prediction of cognitive decline in osteoporosis: a machine learning study.Frontiers in neurology · 2026Article
- Inflammation-mediated regional brain alterations associated with mild cognitive impairment in knee osteoarthritis.Arthritis research & therapy · 2025Article
- Duration of symptoms before diagnosis in degenerative cervical myelopathy: A systematic review and meta-analysis.Brain & spine · 2025Review
- Measuring neuroplasticity in human development: the potential to inform the type and timing of mental health interventions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Resting-state brain plasticity is associated with the severity in cervical spondylotic myelopathy.BMC musculoskeletal disorders · 2024Article
- Systematic investigation of cerebellar functional alterations and their association with surgical outcomes in patients with degenerative cervical myelopathy: a resting-state fMRI study.La Radiologia medica · 2024Article
- Cilostazol protects against degenerative cervical myelopathy injury and cell pyroptosis via TXNIP-NLRP3 pathway.Cell division · 2024Article
- Intra- and inter-network connectivity abnormalities associated with surgical outcomes in degenerative cervical myelopathy patients: a resting-state fMRI study.Frontiers in neurology · 2024Article
- Potential effects of peripheral neuropathy on brain function in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2024Article
- Neural correlates of central pain sensitization in chronic low back pain: a resting-state fMRI study.Neuroradiology · 2023Article
- The role of neuronal plasticity in cervical spondylotic myelopathy surgery: functional assessment and prognostic implication.Neurosurgical review · 2023Review
- Utility of MRI in Quantifying Tissue Injury in Cervical Spondylotic Myelopathy.Journal of clinical medicine · 2023Review
- Preoperative pain hypersensitivity is associated with axial pain after posterior cervical spinal surgeries in degenerative cervical myelopathy patients: a preliminary resting-state fMRI study.Insights into imaging · 2023Article
- Remodeling of the brain correlates with gait instability in cervical spondylotic myelopathy.Frontiers in neuroscience · 2023Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo investigate the brain mechanism of non-correspondence between diseases severity and compression degree of the spinal cord in cervical spondylotic myelopathy (CSM) patients and to test the utility of brain imaging biomarkers for predicting prognosis of CSM.
methodsWe calculated voxel-wise zALFF from 54 CSM patients and 50 healthy controls using resting-state fMRI data. In analysis 1, we identified the brain regions exhibited significant differences of zALFF between CSM patients and healthy controls. In analyses 2 through 3, we investigated the zALFF differences between light-symptom CSM patients and severe-symptom CSM patients while carefully matching the degree of compression between these two groups. In analysis 4, we tested the utility of zALFF within the primary motor cortex (M1) for predicting the prognosis of CSM.
resultsWe found that (1) compared with the healthy controls, CSM patients exhibited higher ALFF within left M1, bilateral superior frontal gyrus, and lower zALFF within right precuneus and calcarine, suggesting altered brain neural activity in CSM patients; (2) after matching the compression degree, the CSM patients with more severe clinical symptoms exhibited higher zALFF within M1, indicating cortical function contributes to disease's severity of CSM; (3) taking the M1 zALFF as features in the prognosis prediction model improves the prediction accuracy, indicating that the M1 zALFF provide additional value for predicting the prognosis of CSM patients following decompression surgery.
conclusionThe functional state of M1 contributes to the disease's severity of CSM and can provide complementary information for predicting the prognosis of CSM following decompression surgery. KEY POINTS: • Cervical spondylotic myelopathy (CSM) patients exhibited increased zALFF within the primary motor cortex (M1), bilateral superior frontal gyrus, and decreased zALFF within the right precuneus and calcarine. • After matching the compression degree, the CSM patients with more severe clinical symptoms exhibited higher zALFF within M1, indicating cortical function contributes to disease severity of CSM. • zALFF within M1 provided additional value for predicting the prognosis of CSM patients.
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