Evidence map›Paper›PMID 35029205›Full record

ArticleMedicine2022

Tranexamic acid use decreases transfusion rate in children with cerebral palsy undergoing proximal femoral varus derotational osteotomy.

Edward Compton, Rachel Y Goldstein, Alexander Nazareth, Stephen J Shymon, Lydia Andras, Robert M Kay

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07095244 (Pediatric Outcomes and Recovery With Peri-Operative Iron Supplement Evaluation), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07095244 narecruitingnot on this mapstarted 2025, after this paper: background citation

Pediatric Outcomes and Recovery With Peri-Operative Iron Supplement Evaluation (PORPOISE)

TypeinterventionalSponsorUniversity of British ColumbiaRan2025 to 2027Enrolled180ConditionsVarus-Derotation Osteotomy Surgery, Iron-deficiency Anemia, Pelvic Osteotomy Surgery, Cerebral PalsyArmsIron Supplement, Comprehensive Nutrition Management
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Preoperative Evaluation of the Child With Cerebral Palsy.Journal of the Pediatric Orthopaedic Society of North America · 2026
    Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Edward ComptonChildren's Orthopaedic Center, Children's Hospital Los Angeles, Los Angeles, CA.
Rachel Y GoldsteinChildren's Orthopaedic Center, Children's Hospital Los Angeles, Los Angeles, CA.
Alexander NazarethChildren's Orthopaedic Center, Children's Hospital Los Angeles, Los Angeles, CA.
Stephen J ShymonDepartment of Orthopaedic Surgery, Harbor-UCLA Medical Center, Torrance, CA.
Lydia AndrasDepartment of Anesthesiology, Children's Hospital Los Angeles, Los Angeles CA.
Robert M KayChildren's Orthopaedic Center, Children's Hospital Los Angeles, Los Angeles, CA.
Children's Hospital of Los Angeles · USOrthopaedic Center · USHarbor–UCLA Medical Center · US

Funding

None NA
6 · The paper itself

Abstract

abstractPrevious studies demonstrated the safety of tranexamic acid (TXA) use in cerebral palsy (CP) patients undergoing proximal femoral varus derotational osteotomy (VDRO), but were underpowered to determine if TXA alters transfusion rates or estimated blood loss (EBL). The purpose of this study was to investigate if intraoperative TXA administration alters transfusion rates or EBL in patients with CP undergoing VDRO surgery.We conducted a retrospective review of 390 patients with CP who underwent VDRO surgery between January 2004 and August 2019 at a single institution. Patients without sufficient clinical data and patients with preexisting bleeding or coagulation disorders were excluded. Patients were divided into 2 groups: those who received intraoperative TXA and those who did not.Out of 390 patients (mean age 9.4 ± 3.8 years), 80 received intravenous TXA (TXA group) and 310 did not (No-TXA group). There was no difference in mean weight at surgery (P = .25), Gross Motor Function Classification System level (P = .99), American Society of Anesthesiologist classification (P = .50), preoperative feeding status (P = .16), operative time (P = .91), or number of procedures performed (P = .12) between the groups. The overall transfusion rate was lower in the TXA group (13.8%; 11/80) than the No-TXA group (25.2%; 78/310) (P = .04), as was the postoperative transfusion rate (7.5%; 6/80 in the TXA group vs 18.4%; 57/310 in the No-TXA group) (P = .02). The intraoperative transfusion rate was similar for the 2 groups (TXA: 7.5%; 6/80 vs No-TXA: 10.3%; 32/310; P = .53). The EBL was slightly lower in the TXA group, although this was not significant (TXA: 142.9 ± 113.1 mL vs No-TXA: 177.4 ± 169.1 mL; P = .09). The standard deviation for EBL was greater in the No-TXA group due to more high EBL outliers. The percentage of blood loss based on weight was similar between the groups (TXA: 9.2% vs No-TXA: 10.1%; P = .40). The number needed to treat (NNT) with TXA to avoid one peri-operative blood transfusion in this series was 9.The use of intraoperative TXA in patients with CP undergoing VDRO surgery lowers overall and postoperative transfusion rates.Level of evidence: III, Retrospective Comparative Study.

Indexed as

AdolescentAntifibrinolytic AgentsBlood Loss, SurgicalBlood TransfusionCerebral PalsyChildChild, PreschoolHumansOsteotomyRetrospective StudiesTranexamic AcidTreatment OutcomeAntifibrinolytic AgentsTranexamic Acid

Identifiers

PMID35029205
PMCPMC8757939
OpenAlexW4205725941

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.