Evidence map›Paper›PMID 35029027›Full record

ArticleJournal of cellular and molecular medicine2022

Alterations of nitric oxide homeostasis as trigger of intestinal barrier dysfunction in non-alcoholic fatty liver disease.

Anja Baumann, Dragana Rajcic, Annette Brandt, Victor Sánchez, Finn Jung, Raphaela Staltner, Anika Nier, Michael Trauner, Katharina Staufer, Ina Bergheim

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Elevated Markers of Intestinal Barrier Dysfunction and TLR2 Ligands in Individuals with Type 1 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Anja BaumannDepartment of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria.
Dragana RajcicDepartment of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria.ORCID 0000-0002-6844-8878
Annette BrandtDepartment of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria.
Victor SánchezDepartment of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria.
Finn JungDepartment of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria.
Raphaela StaltnerDepartment of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria.
Anika NierDepartment of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria.
Michael TraunerDivision of Gastroenterology & Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Katharina StauferDivision of Gastroenterology & Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Ina BergheimDepartment of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria.ORCID 0000-0002-3356-4115
University of Vienna · ATMedical University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Changes in intestinal nitric oxide metabolism are discussed to contribute for the development of intestinal barrier dysfunction in non-alcoholic fatty liver disease (NAFLD). To induce steatosis, female C57BL/6J mice were pair-fed with a liquid control diet (C) or a fat-, fructose- and cholesterol-rich diet (FFC) for 8 weeks. Mice received the diets ± 2.49 g L-arginine/kg bw/day for additional 5 weeks. Furthermore, mice fed C or FFC ± L-arginine/kg bw/day for 8 weeks were concomitantly treated with the arginase inhibitor N

Indexed as

Non-alcoholic Fatty Liver DiseaseAnimalsArginineFemaleHomeostasisHumansLiverMiceMice, Inbred C57BLNitric OxideToll-Like Receptor 4ArginineNitric OxideToll-Like Receptor 4arginase activityendotoxinintestinal barrier functionL-argininenon-alcoholic steatohepatitis

Identifiers

PMID35029027
PMCPMC8831936
OpenAlexW4205809897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.