Evidence map›Paper›PMID 35028922›Full record

ArticleHepatology international2022

Reciprocal alterations in circulating and hepatic gamma-delta T cells in patients with primary biliary cholangitis.

Sha Chen, Tingting Lv, Guangyong Sun, Shuxiang Li, Weijia Duan, Chunpan Zhang, Hua Jin, Dan Tian, Mingyang Li, Shan Shan and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Hepatology international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. γδ T cells in colorectal and liver cancer.Nature reviews. Gastroenterology & hepatology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Sha ChenLiver Research Center, Beijing Friendship Hospital, Capital Medical University, 95 Yong-an Road, Beijing, 100050, China.
Tingting LvLiver Research Center, Beijing Friendship Hospital, Capital Medical University, 95 Yong-an Road, Beijing, 100050, China.
Guangyong SunExperimental and Translational Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Shuxiang LiLiver Research Center, Beijing Friendship Hospital, Capital Medical University, 95 Yong-an Road, Beijing, 100050, China.
Weijia DuanLiver Research Center, Beijing Friendship Hospital, Capital Medical University, 95 Yong-an Road, Beijing, 100050, China.
Chunpan ZhangExperimental and Translational Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Hua JinExperimental and Translational Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Dan TianExperimental and Translational Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Mingyang LiExperimental and Translational Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Shan ShanLiver Research Center, Beijing Friendship Hospital, Capital Medical University, 95 Yong-an Road, Beijing, 100050, China.
Hong MaLiver Research Center, Beijing Friendship Hospital, Capital Medical University, 95 Yong-an Road, Beijing, 100050, China.
Xiaojuan OuLiver Research Center, Beijing Friendship Hospital, Capital Medical University, 95 Yong-an Road, Beijing, 100050, China.
Hong YouLiver Research Center, Beijing Friendship Hospital, Capital Medical University, 95 Yong-an Road, Beijing, 100050, China.
Dong ZhangExperimental and Translational Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China. zhangd@ccmu.edu.cn.
Jidong JiaLiver Research Center, Beijing Friendship Hospital, Capital Medical University, 95 Yong-an Road, Beijing, 100050, China. jia_jd@ccmu.edu.cn.ORCID http://orcid.org/0000-0002-4673-8890
Capital Medical University · CNBeijing University of Technology · CN

Funding

National Natural Science Foundation of China 82000533
6 · The paper itself

Abstract

BACKGROUND AND

aimsGamma-delta (γδ) T cells are involved in the development of diverse liver and autoimmune diseases, whereas the role of γδ T cells in primary biliary cholangitis (PBC) remains unclear.

methodsWe analyzed the number, phenotypes, and functional molecules of both circulating and hepatic γδ T cells in PBC patients and healthy controls (HCs) by flow cytometric analysis and immunohistochemistry.

resultsWe identified two distinct functional subsets of circulating γδ T cells according to the CD3/TCRγδ complex: the TCRγδ

conclusionThe circulating TCRγδ

Indexed as

Intraepithelial LymphocytesLiver Cirrhosis, BiliaryHumansReceptors, Antigen, T-Cell, gamma-deltaUrsodeoxycholic AcidReceptors, Antigen, T-Cell, gamma-deltaUrsodeoxycholic AcidAutoimmune liver diseaseCXCR6FunctionGranzyme BPrimary biliary cirrhosisSubpopulationSubsetTCRUnconventional T cellsVδ2γδ T cells

Identifiers

PMID35028922
OpenAlexW4206333715

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.