Evidence map›Paper›PMID 35028899›Full record

ArticleMolecular neurobiology2022

Rapid Treatment with Intramuscular Magnesium Sulfate During Cardiopulmonary Resuscitation Does Not Provide Neuroprotection Following Cardiac Arrest.

Rui Zhang, Timothy D Bryson, Garrett M Fogo, Jinhui Liao, Sarita Raghunayakula, Jennifer Mathieu, Joseph M Wider, Xiaodan Ren, Kathleen J Maheras, Katlynn J Emaus and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. The role of magnesium in cardiac arrest.Frontiers in nutrition · 2024
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Rui ZhangDepartment of Emergency Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Timothy D BrysonDepartment of Emergency Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Garrett M FogoDepartment of Emergency Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Jinhui LiaoDepartment of Emergency Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Sarita RaghunayakulaDepartment of Emergency Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Jennifer MathieuDepartment of Emergency Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Joseph M WiderDepartment of Emergency Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Xiaodan RenDepartment of Emergency Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Kathleen J MaherasDepartment of Emergency Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Katlynn J EmausDepartment of Emergency Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Erin GruleyDepartment of Emergency Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Yuguo ChenDepartment of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, 250012, China.
Robert W NeumarDepartment of Emergency Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. neumar@umich.edu.
Thomas H SandersonDepartment of Emergency Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. thsand@umich.edu.
University of Michigan–Ann Arbor · USQilu Hospital of Shandong University · CN

Funding

TRAINING IN MOLECULAR AND CELLULAR CARDIOLOGYT32HL007853 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David J. Pinsky · 1996 to 2026
$11.6M
Non-invasive mitochondrial modulation therapy for ischemic strokeR01NS120322 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUETTEMANN, MAIK, SANDERSON, THOMAS HUDSON · 2021 to 2025
$2.3M
Limiting brain reperfusion injury by controlling mitochondrial functionR01NS091242 · NINDS · WAYNE STATE UNIVERSITY · PI HUETTEMANN, MAIK, SANDERSON, THOMAS HUDSON · 2015 to 2018
$1.3M
American Heart Association 19SFRN34830008NHLBI NIH HHS T32 HL007853NHLBI NIH HHS T32HL007853NINDS NIH HHS R01 NS091242NINDS NIH HHS R01NS091242NINDS NIH HHS R01 NS120322NINDS NIH HHS R01NS120322
6 · The paper itself

Abstract

Brain injury is the most common cause of death for patients resuscitated from cardiac arrest. Magnesium is an attractive neuroprotective compound which protects neurons from ischemic injury by reducing neuronal calcium overload via NMDA receptor modulation and preventing calcium-induced mitochondrial permeability transition. Intramuscular (IM) delivery of MgSO

Indexed as

Cardiopulmonary ResuscitationHeart ArrestAnimalsMagnesium SulfateMaleNeuroprotectionRatsRats, Long-EvansMagnesium SulfateBrain ischemiaCardiac arrestMagnesiumNeuroprotection

Identifiers

PMID35028899
PMCPMC8882154
OpenAlexW4205193743

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.