Evidence map›Paper›PMID 35028890›Full record

Trial reportEndocrine2022

Effect of high dose vitamin D supplementation on indices of sarcopenia and obesity assessed by DXA among older adults: A randomized controlled trial.

Jana Jabbour, Maya Rahme, Ziyad R Mahfoud, Ghada El-Hajj Fuleihan

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Endocrine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01315366 (Phase III Study on the Effect of Vitamin D Supplementation on Indices of Mineral and Musculoskeletal Metabolism and on Parameters of Glucose and Fuel Metabolism in Elderly Subjects), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01315366 phase3completednot on this map

Phase III Study on the Effect of Vitamin D Supplementation on Indices of Mineral and Musculoskeletal Metabolism and on Parameters of Glucose and Fuel Metabolism in Elderly Subjects

TypeinterventionalSponsorAmerican University of Beirut Medical CenterRan2011 to 2015Enrolled257ConditionsHypovitaminosis D, Insulin Resistance, Obesity, OsteoporosisArmsEuro D and Ci-CalD, Euro D, Ci-CalD
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Jana JabbourDepartment of Nutrition, School of Health Sciences, Modern University for Business and Sciences, Beirut, Lebanon.ORCID http://orcid.org/0000-0002-0576-1031
Maya RahmeDepartment of Internal Medicine, Division of Endocrinology, Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, American University of Beirut Medical Center, Beirut, Lebanon.
Ziyad R MahfoudDepartment of Medical Education, Weill Cornell Medicine, Doha, Qatar.ORCID http://orcid.org/0000-0003-4098-6401
Ghada El-Hajj FuleihanDepartment of Internal Medicine, Division of Endocrinology, Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, American University of Beirut Medical Center, Beirut, Lebanon. gf01@aub.edu.lb.ORCID http://orcid.org/0000-0002-2076-5858
American University of Beirut Medical Center · LBCornell University · USModern University for Business and Science · LB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypovitaminosis D is associated with Sarcopenic Obesity (SO), but evidence from randomized Vitamin D 3 (VD3) trials is scarce.

objectiveCompare the effect of VD3 supplementation, at two doses, on SO indices at 12 months.

methodsOverweight older adults (>65 years) with baseline 25-hydroxyvitamin D (25OHD) of 10-30 ng/mL were recruited in this double-blind, randomized, controlled multicenter trial (clinicaltrial.gov identifier: NCT01315366). All subjects received 1000 mg calcium citrate/day and underwent total body Dual-energy X-ray Absorptiometry for body composition assessment. Low Dose Group (LDG) and High Dose Group (HDG) received 600 IU -Institute of Medicine (IOM) Recommended Dietary Allowance (RDA)- and 3750 IU VD3/day, respectively.

resultsMean age was 71 ± 4.6 years, 55% females, BMI: 30.2 ± 4.5 Kg/m

conclusionsWeekly VD3, at the daily equivalent of 3750 IU/day, did not improve indices of sarcopenia nor adiposity compared to the IOM RDA dose in adults.

Indexed as

SarcopeniaAbsorptiometry, PhotonAgedCholecalciferolDietary SupplementsDouble-Blind MethodFemaleHumansMaleObesityVitamin DVitaminsCholecalciferolVitamin DVitaminsObesitySarcopeniaVisceral adipose tissuesVitamin D

Identifiers

PMID35028890
OpenAlexW4205594897

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.