ReviewJournal of experimental orthopaedics2022
The novel epiligament theory: differences in healing failure between the medial collateral and anterior cruciate ligaments.
Review in Journal of experimental orthopaedics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 19 citations in OpenAlex.
- The role ofEuropean journal of translational myology · 2026Article
- Functional Outcomes of Anatomic Anterior Cruciate Ligament Reconstruction Using Retrograde Femoral Socket Drilling via a Far Anteromedial Portal Combined with a Conventional Antegrade Tibial Tunnel: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Clinical Effectiveness and Magnetic Resonance Imaging-Based Endurability of Matrix-Associated Autologous Chondrocyte Implantation with an Autologous Periosteal Flap for Articular Cartilage Defects of the Knee Joint.Journal of clinical medicine · 2026Article
- Contraindications to Lateral Extra-Articular Tenodesis: A Systematic Review.Journal of clinical medicine · 2026Review
- Combined ACL and ALL Reconstruction Using Allografts as the ACL Graft Source Reduces Surgical Failure and Improves Graft Maturity Compared with Isolated ACL Reconstruction.Journal of clinical medicine · 2026Article
- Can the Spatial Heterogeneity in the Epiligament Explain the Differential Healing Capacities of the ACL and MCL?Journal of clinical medicine · 2026Article
- High Tibial Osteotomy Is Associated with Improvements in Both Knee and Ankle Alignment in Medial Compartment Osteoarthritis.Journal of clinical medicine · 2026Article
- Evaluating Tibial Tunnel Landmarks in Anterior Cruciate Ligament Reconstruction: Remnant Versus Lateral Meniscus Anterior Horn.Journal of clinical medicine · 2025Article
- Technical Details of Lateral Tenodesis at the Fascia Lata: A Systematic Review of the Literature.Journal of clinical medicine · 2025Review
- The Effect of IL-17A and Combined Mechanical Injury on Meniscal Tissue Integrity In Vitro.Journal of clinical medicine · 2025Article
- Comparison of cellular activity and gene expression in repaired versus reconstructed anterior cruciate ligaments: A case-control study.Journal of experimental orthopaedics · 2025Article
- Should We Accept the Epiligament Theory About the Differences in the Healing Potential of the Medial Collateral and the Anterior Cruciate Ligament?Biomedicines · 2025Article
- Article
- New insight into the morphological characteristics of patella cubiti.Surgical and radiologic anatomy : SRA · 2023Article
- Anatomical Tissue Engineering of the Anterior Cruciate Ligament Entheses.International journal of molecular sciences · 2023Review
- [Diagnosis and treatment progress in the femoral insertion injury of medial collateral ligament of knee].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023Article
- ACL repair for athletes?Journal of orthopaedicsArticle
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to current literature, 90% of knee ligament injuries involve the medial collateral ligament or the anterior cruciate ligament. In contrast to the medial collateral ligament, which regenerates relatively well, the anterior cruciate ligament demonstrates compromised healing. In the past, there were numerous studies in animal models that examined the healing process of these ligaments, and different explanations were established. Although the healing of these ligaments has been largely investigated and different theories exist, unanswered questions persist.Therefore, the aim of this article is 1) to review the different historical aspects of healing of the medial collateral ligament and present the theories for healing failure of the anterior cruciate ligament; 2) to examine the novel epiligament theory explaining the medial collateral ligament healing process and failure of anterior cruciate ligament healing; and 3) to discuss why the enveloping tissue microstructure of the aforementioned ligaments needs to be examined in future studies.We believe that knowledge of the novel epiligament theory will lead to a better understanding of the normal healing process for implementing optimal treatments, as well as a more holistic explanation for anterior cruciate ligament healing failure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.