ArticleArchives of orthopaedic and trauma surgery2023
Spacer exchange in persistent periprosthetic joint infection: microbiological evaluation and survivorship analysis.
Article in Archives of orthopaedic and trauma surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Identifying potential predictive indicators for reimplantation timing in two-stage revision: a meta-analysis and system review.Archives of orthopaedic and trauma surgery · 2024Pooled it
- Outcomes of Surgical Strategies for Prosthetic Joint Infection Following Unicompartmental Knee Arthroplasty: A 2-Year Follow-up.Clinics in orthopedic surgery · 2026Article
- Search for Potentially VirulentInternational journal of molecular sciences · 2026Article
- Revision of a Dislocated Articulating Antibiotic Hip Spacer as an Alternative to Girdlestone Arthroplasty: A Case Report.Journal of orthopaedic case reports · 2026Article
- Differential impact of single interim spacer exchanges on survival outcomes in two-stage exchange arthroplasty for PJIs: a comparative analysis with minimum 5-year follow-up.BMC musculoskeletal disorders · 2026Article
- Bibliometric Analysis of Outpatient Hip and Knee Arthroplasty Research Evolution.The archives of bone and joint surgery · 2025Article
- Periprosthetic Joint Infection (PJI).The archives of bone and joint surgery · 2025Review
- The pathogenicity and virulence of the opportunistic pathogenVirulence · 2024Review
- Unbalanced metaphyseal fixation is associated with an increased aseptic loosening of revision total knee arthroplasty at mean 4-year follow-up.Archives of orthopaedic and trauma surgery · 2024Article
- Impact of unplanned second debridement, antibiotics and implant retention on long-term outcomes in knee exchange arthroplasty: Elevated risk of failure and reinfection.Journal of experimental orthopaedics · 2024Article
- Two-stage revision in periprosthetic joint infection of the hip using a new intraoperatively molded articulating spacer design.Journal of clinical orthopaedics and trauma · 2023Article
- Clinical impact of microbiological results in two-stage revision arthroplasty with spacer exchange.Archives of orthopaedic and trauma surgery · 2023Article
- Two-stage revision for periprosthetic joint infection in unicompartmental knee arthroplasty: clinical and radiological results.Archives of orthopaedic and trauma surgery · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purposes of this study were to determine demographics and characteristics of patients who underwent spacer exchange for persistent infection in the setting of two-stage arthroplasty for periprosthetic joint infection, to describe the microbiology of pathogens involved, to analyze survivorship free from infection in these patients.
methodsThe institutional prospectively collected database was reviewed to enroll patients with minimum 2 years follow-up. Patients who underwent two-stage procedure for septic arthritis were excluded, as were patients who had spacer fracture or dislocation.
resultsA total of 34 patients (41 procedures) were included. Mean age was 65.0 ± 12.8 years. Mean follow-up was 53.4 ± 24.8 months. Mean number of previous procedures was 3.6 ± 1.2. A total of 27 (79.4%) patients underwent final reimplantation. The most frequently isolated pathogen in spacer exchange was Staphylococcus epidermidis (10 cases, 28.6%). Polymicrobial cultures were obtained from 9 (25.71%) patients, 10 (28.6%) presented culture-negative infections. A total of 11 (32.4%) resistant pathogens were isolated, and 16 (47.0%) difficult to treat pathogens were detected. Eradication rate was 78.8%. Overall survivorship of implants after final reimplantation was 72.8% at 51.8 months.
conclusionSurgeons should be aware that subjects necessitating spacer exchange often present multiple comorbidities, previous staged revision failures, soft-tissue impairment and difficult to treat infection. In these patients, spacer exchange provides good clinical results and infection eradication, preventing arthrodesis or amputation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.