Evidence map›Paper›PMID 35028695›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2022

Incidence of synchronous contralateral tonsillar malignancy in a known case of unilateral tonsillar carcinoma.

Sara Mahmood, Tauseef Ahmed, Olaleye Oladejo, Manish Mair, Rihab Fagiry, Mohammed H Hussain, Mandy Eltayeb, Shoaib Ahmad, Andrew Baker, Ram Vaidhyanath and 1 more

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

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1citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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1 citing paper in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Sara MahmoodMaxillofacial Department, University Hospital of Leicester, Leicester, UK.
Tauseef AhmedMaxillofacial Department, University Hospital of Leicester, Leicester, UK.
Olaleye OladejoHead and Neck Surgery, University Hospital of Leicester, Leicester, UK.
Manish MairMaxillofacial Department, University Hospital of Leicester, Leicester, UK. manishmair@gmail.com.ORCID http://orcid.org/0000-0003-3957-2738
Rihab FagiryMaxillofacial Department, University Hospital of Leicester, Leicester, UK.
Mohammed H HussainDepartment of Otorhinolaryngology, University Hospital of Leicester, Leicester, UK.
Mandy EltayebMaxillofacial Department, University Hospital of Leicester, Leicester, UK.
Shoaib AhmadClinical Oncology, University Hospital of Leicester, Leicester, UK.
Andrew BakerMaxillofacial Department, University Hospital of Leicester, Leicester, UK.
Ram VaidhyanathRadiology Department, University Hospital of Leicester, Leicester, UK.
Peter ConboyHead and Neck Surgery, University Hospital of Leicester, Leicester, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe literature is divided with regards to contralateral tonsillectomy in a known/suspected case of ipsilateral tonsillar malignancy. In this study, we evaluate the incidence of indolent synchronous contralateral tonsillar malignancy (SCTC) in patients with known ipsilateral tonsillar malignancy.

methodsAll patients diagnosed with ipsilateral tonsillar carcinoma (TC) at a tertiary teaching center between January 2016 and December 2019 were screened. None of the patients were suspected to have bilateral TC. All patients underwent appropriate imaging in the form of Magnetic resonance imaging and computed tomography of head and neck region and then underwent bilateral tonsillectomy. The prevalence of bilateral tonsillar malignancy and the factors predicting them were analyzed.

resultsIn all 59 patients were included in the study. The mean and median age of the patient population was 60.8 and 59 years, respectively, with a male to female ratio of 3.2:1. The incidence of bilateral tonsillar malignancy in carcinoma of unknown primary (CUP) was 3/10 (33.3%). Among the remaining 49 patients, incidence of synchronous contralateral tonsillar carcinoma (SCTC) was 2/49 (4.08%). Overall, 5/59 (8.5%) patients had synchronous bilateral tonsillar malignancy. Furthermore, dysplasia was found in the contralateral tonsil in 4/10 (40%) CUP patients. Among the remaining 49 patients, dysplasia was seen in the contralateral tonsil in 20/49 (40.8%) patients. The absence of p16 expression predicted higher probability of SCTC. Factors like gender, T stage, nodal status or smoking did not predict SCTC.

conclusionWe recommend bilateral tonsillectomy in all patients with suspected or proven TC (unilateral or bilateral) and CUP as it helps identify indolent SCTC and it does not add any significant morbidity to the patients. LEVEL OF EVIDENCE: III.

Indexed as

Carcinoma, Squamous CellNeoplasms, Unknown PrimaryTonsillar NeoplasmsTonsillectomyFemaleHumansIncidenceMaleMiddle AgedPalatine TonsilRetrospective StudiesCUPHPVp16 statusSynchronous second primaryTonsillar malignancy

Identifiers

PMID35028695

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