Evidence map›Paper›PMID 35028556›Full record

ArticleMaterials today. Bio2022

Engineering a naturally derived hemostatic sealant for sealing internal organs.

Sevana Baghdasarian, Bahram Saleh, Avijit Baidya, Hanjun Kim, Mahsa Ghovvati, Ehsan Shirzaei Sani, Reihaneh Haghniaz, Shashank Madhu, Maria Kanelli, Iman Noshadi and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. One-Pot Synthesis of Antibacterial and Antioxidant Self-Healing Bioadhesives Using Ugi Four-Component Reactions.Journal of biomedical materials research. Part B, Applied biomaterials · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. An All-In-One Transient Theranostic Platform for Intelligent Management of Hemorrhage.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  10. Article
  11. Review
  12. Application of photo-crosslinkable gelatin methacryloyl in wound healing.Frontiers in bioengineering and biotechnology · 2023
    Review
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Sevana BaghdasarianDepartment of Chemical and Biomolecular Engineering, University of California - Los Angeles, Los Angeles, CA, 90095, USA.
Bahram SalehDepartment of Chemical Engineering Northeastern University, Boston, MA, 02115, USA.
Avijit BaidyaDepartment of Chemical and Biomolecular Engineering, University of California - Los Angeles, Los Angeles, CA, 90095, USA.
Hanjun KimCenter for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute (CNSI), University of California - Los Angeles, Los Angeles, CA, 90095, USA.
Mahsa GhovvatiDepartment of Chemical and Biomolecular Engineering, University of California - Los Angeles, Los Angeles, CA, 90095, USA.
Ehsan Shirzaei SaniDepartment of Chemical and Biomolecular Engineering, University of California - Los Angeles, Los Angeles, CA, 90095, USA.
Reihaneh HaghniazCenter for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute (CNSI), University of California - Los Angeles, Los Angeles, CA, 90095, USA.
Shashank MadhuDepartment of Chemical Engineering Northeastern University, Boston, MA, 02115, USA.
Maria KanelliSchool of Chemical Engineering, National Technical University of Athens, Zografou Campus, Athens, 15780, Greece.
Iman NoshadiDepartment of Bioengineering, University of California, Riverside, 92507, USA.
Nasim AnnabiDepartment of Chemical and Biomolecular Engineering, University of California - Los Angeles, Los Angeles, CA, 90095, USA.
University of California, Los Angeles · USCalifornia NanoSystems Institute · USNortheastern University · USNational Technical University of Athens · GRUniversity of California, Riverside · US

Funding

Engineering highly elastic surgical sealants with hemostatic propertiesR01HL140618 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANNABI, NASIM, KHADEMHOSSEINI, ALI · 2018 to 2021
$2.8M
Engineering a naturally derived and highly adhesive surgical sealantR01EB023052 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANNABI, NASIM, KHADEMHOSSEINI, ALI · 2017 to 2022
$2.4M
NHLBI NIH HHS R01 HL140618NIBIB NIH HHS R01 EB023052
6 · The paper itself

Abstract

Controlling bleeding from a raptured tissue, especially during the surgeries, is essentially important. Particularly for soft and dynamic internal organs where use of sutures, staples, or wires is limited, treatments with hemostatic adhesives have proven to be beneficial. However, major drawbacks with clinically used hemostats include lack of adhesion to wet tissue and poor mechanics. In view of these, herein, we engineered a double-crosslinked sealant which showed excellent hemostasis (comparable to existing commercial hemostat) without compromising its wet tissue adhesion. Mechanistically, the engineered hydrogel controlled the bleeding through its wound-sealing capability and inherent chemical activity. This mussel-inspired hemostatic adhesive hydrogel, named gelatin methacryloyl-catechol (GelMAC), contained covalently functionalized catechol and methacrylate moieties and showed excellent biocompatibility both

Indexed as

BioadhesiveDopamine-conjugationDouble-crosslinked networkHemostaticPhotocrosslinking

Identifiers

PMID35028556
PMCPMC8741525
OpenAlexW4200292657

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.