Evidence map›Paper›PMID 35028529›Full record

ArticleiScience2022

Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome.

Ashley S Williams, Timothy R Koves, Yasminye D Pettway, James A Draper, Dorothy H Slentz, Paul A Grimsrud, Olga R Ilkayeva, Deborah M Muoio

Open access · goldAbstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Nicotinamide Riboside, a Promising Vitamin BMolecules (Basel, Switzerland) · 2023
    Review
  7. Review
  8. Article
  9. NADSports medicine (Auckland, N.Z.) · 2022
    Review
  10. Article
  11. Balancing NADCellular and molecular life sciences : CMLS · 2022
    Review
  12. Article
  13. Sirtuin 3 Dependent and Independent Effects of NADAntioxidants (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ashley S WilliamsDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA.
Timothy R KovesDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA.
Yasminye D PettwayDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA.
James A DraperDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA.
Dorothy H SlentzDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA.
Paul A GrimsrudDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA.
Olga R IlkayevaDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA.
Deborah M MuoioDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA.
Duke University · US

Funding

Pilot & Feasibility ProgramP30DK124723 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Nicholette D. Allred · 2020 to 2026
$11.0M
Role of Carnitine Acetyltransferase in Mitochondrial and Metabolic FunctionR01DK089312 · NIDDK · DUKE UNIVERSITY · PI DEBORAH M MUOIO · 2010 to 2026
$7.8M
Mitochondrial Protein Acetylation and Energy Metabolism in MuscleF32DK105922 · NIDDK · DUKE UNIVERSITY · PI WILLIAMS, ASHLEY SILBERMAN · 2015 to 2017
$163k
NIDDK NIH HHS F32 DK105922NIDDK NIH HHS P30 DK124723NIDDK NIH HHS R01 DK089312
6 · The paper itself

Abstract

Nicotinamide riboside supplements (NRS) have been touted as a nutraceutical that promotes cardiometabolic and musculoskeletal health by enhancing nicotinamide adenine dinucleotide (NAD

Indexed as

NutritionPhysiologyProteomics

Identifiers

PMID35028529
PMCPMC8741497
OpenAlexW4200597370

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.