Evidence map›Paper›PMID 35028301›Full record

ArticleCanadian journal of gastroenterology & hepatology2022

Preoperative Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and CEA as the Potential Prognostic Biomarkers for Colorectal Cancer.

Fu Ming-Sheng, Du Mei-Ling, Cai Xun-Quan, Hu Yuan-Xin, Zhang Wei-Jie, Pan Qin-Cong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of gastroenterology & hepatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Fu Ming-ShengDepartment of Gastroenterology, Shanghai Fifth People's Hospital Fudan University, No. 801, Heqing Road, Minhang District, Shanghai 200240, China.ORCID 0000-0001-7769-8257
Du Mei-LingDepartment of Gastroenterology, Shanghai Fifth People's Hospital Fudan University, No. 801, Heqing Road, Minhang District, Shanghai 200240, China.
Cai Xun-QuanDepartment of Gastroenterology, Shanghai Fifth People's Hospital Fudan University, No. 801, Heqing Road, Minhang District, Shanghai 200240, China.
Hu Yuan-XinDepartment of Gastroenterology, Shanghai Fifth People's Hospital Fudan University, No. 801, Heqing Road, Minhang District, Shanghai 200240, China.
Zhang Wei-JieDepartment of Gastroenterology, Shanghai Fifth People's Hospital Fudan University, No. 801, Heqing Road, Minhang District, Shanghai 200240, China.
Pan Qin-CongDepartment of Gastroenterology, Shanghai Fifth People's Hospital Fudan University, No. 801, Heqing Road, Minhang District, Shanghai 200240, China.
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study was to evaluate the prognostic value of the preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and carcinoembryonic antigen (CEA) in colorectal cancer (CRC) patients and to identify the potential and easily accessible prognostic biomarkers for CRC. Methods: We retrospectively reviewed altogether the records of 330 CRC patients according to inclusion criteria. The clinical characteristics include age at diagnosis, body mass index (BMI), preoperative CEA level, neutrophil , lymphocyte, and platelet count, tumor primary site and size, clinical pathological TNM stage, and survival status were recorded through the review of medical records. The overall survival (OS) was calculated using the Kaplan-Meier method. The Cox proportional hazards model was used for the univariate and multivariate analysis to evaluate the prognostic factors of CRC. Results: A total of 330 patients were finally included in the current study. The mean follow-up duration was 32.8 ± 19.1 months (range, 0.1-67.7). Compared with the median OS, preoperative high NLR, PLR, and CEA, and low BMI had lower median OS. The NLR and PLR value rise indicates lower median OS in stage I-II CRC; however, the NLR value and CEA level rise indicates lower median OS in stage III-IV CRC. Preoperative high NLR, PLR, and CEA level and low BMI have poorer OS by univariate analysis. By multivariate analysis, the age, sex, N, M stage, and BMI demonstrated independently influence the OS of CRC. NLR was an independent predictor of stage I-II CRC, and the CEA level was an independent predictor of stage III-IV CRC. Conclusions: Our results show that preoperative high NLR, PLR, CEA, and low BMI had poorer OS, NLR was an independent predictor of stage I-II CRC, and the CEA level was an independent predictor of stage III-IV CRC.

Indexed as

Carcinoembryonic AntigenColorectal NeoplasmsBiomarkers, TumorHumansLymphocytesNeutrophilsPrognosisRetrospective StudiesBiomarkers, TumorCarcinoembryonic Antigen

Identifiers

PMID35028301
PMCPMC8752269
OpenAlexW4205906082

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.