ArticleJournal of dental sciences2022
Effect of humic acid as a photosensitizer combined with low-energy laser on orthodontic tooth movement in rats.
Article in Journal of dental sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Biphasic energy dependent effects of 650 nm diode laser photobiomodulation on orthodontic tooth movement and compression zone bone remodeling in vivo.BMC oral health · 2026Article
- Low-Level Laser Therapy, Photobiomodulation, and Photodynamics with Photosensitizer Combination in Dentistry: A Systematic Review.Journal of lasers in medical sciences · 2026Review
- How do infrared and near-infrared lasers influence autophagy and alveolar bone remodeling in rats during orthodontic tooth retention?BMC oral health · 2025Article
- Humic acid from vermicompost effectively regulates the redox status and mitigates the progression of experimental periodontitis.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Effect of photobiological regulation of green laser on orthodontic tooth retention in rats.Lasers in medical science · 2025Article
- Humic Acid Derived from Agricultural Biomass Mitigates Alveolar Bone Loss and Modulates Systemic Inflammatory Cytokines in Rats with Periodontitis.Current topics in medicinal chemistry · 2025Article
- The effects of fulvic acids and low-level laser therapy on orthodontic retention in rats.BMC oral health · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background/purposeHumic acid (HA) could promote light conversion reaction, and lasers accelerate orthodontic tooth movement. We investigated the effect of HA, as a photosensitizer, combined with low-energy laser on orthodontic tooth movement in rats. MATERIALS AND
methodsAn orthodontic tooth movement model was established, and the upper left first molar was moved mesially by a nickel-titanium tension spring with a 50-g force. HA was injected into the rats' abdominal cavity (80 mg/kg once daily). The periodontal tissue of the upper left upper first molar on the pressure side was irradiated (50 s once every 2 days) using a semiconductor laser (wavelength, 650 nm; power, 50 mV). Distance moved by the upper left first molar was measured at different time points, and the tissue of the first molar was sectioned and scanned by micro-computed tomography to evaluate the alveolar bone density. Tartrate-resistant acidic phosphatase staining was used to observe the osteoclast number, alveolar bone, and periodontal tissue.
resultsHA alone did not significantly affect orthodontic tooth movement, alveolar structure density, or periodontal tissue remodeling (P > 0.05). HA combined with a low-energy laser accelerated orthodontic tooth movement. The number of bone absorption lacunae and osteoclasts on the alveolar bone's pressure side increased significantly (P < 0.05), while the density decreased significantly (P < 0.05); however, no root absorption was observed.
conclusionHA can improve the conversion rate of low-energy lasers, enhance the low-energy laser effect, and promote orthodontic tooth movement and periodontal tissue reconstruction on the pressure side in rats, without causing root resorption.
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