Evidence map›Paper›PMID 35027963›Full record

SynthesisJournal of medicine and life

The economic burden of stroke: a systematic review of cost of illness studies.

Stefan Strilciuc, Diana Alecsandra Grad, Constantin Radu, Diana Chira, Adina Stan, Marius Ungureanu, Adrian Gheorghe, Fior-Dafin Muresanu

Registry-linked trialAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of medicine and life. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06887231 (Virtual Reality), which is not on this map. Cited by 117 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06887231 narecruitingnot on this map

Virtual Reality (VR) Platform and Transcutaneous Electrical Nerve Stimulation (TENS) for Early Stroke Rehabilitation

TypeinterventionalSponsorMedical University of ViennaRan2025 to 2027Enrolled35ConditionsStrokeArmsVR+TENS, Conventional rehabilitation
3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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  8. Systematic review: Resting state functional MRI as a biomarker for non-invasive brain stimulation in upper limb recovery post-stroke.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Stefan StrilciucDepartment of Neuroscience, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Diana Alecsandra GradRoNeuro Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania.
Constantin RaduRoNeuro Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania.
Diana ChiraRoNeuro Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania.
Adina StanDepartment of Neuroscience, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Marius UngureanuDepartment of Public Health, Faculty of Political, Administrative and Communication Sciences, Babes-Bolyai University, Cluj-Napoca, Romania.
Adrian GheorgheDepartment of Infectious Disease Epidemiology, Global Health and Development Group, Imperial College London, London, United Kingdom.
Fior-Dafin MuresanuDepartment of Neuroscience, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stroke is one of the leading causes of morbidity and mortality worldwide. As the number of stroke cases is rising from one year to another, policymakers require data on the amount spent on stroke to enforce better financing policies for prevention, hospital care, outpatient rehabilitation services and social services. We aimed to systematically assess the economic burden of stroke at global level. Cost of stroke studies were retrieved from five databases. We retrieved the average cost per patient, where specified, or estimated it using a top-down approach. Resulting costs were grouped in two main categories: per patient per year and per patient lifetime. We extracted information from forty-six cost of illness studies. Per patient per year costs are larger in high income countries and in studies conducted from the payer perspective. The highest average per patient per year cost by country was reported in the United States ($59,900), followed by Sweden ($52,725) and Spain ($41,950). The highest per patient lifetime costs were reported in Australia ($232,100) for all identified definitions of stroke. Existing literature regarding the economic burden of stroke is concentrated in high-income settings, with very few studies conducted in South America and Africa. Published manuscripts on this topic highlight substantial methodological heterogeneity, rendering comparisons difficult or impossible, even within the same country or among studies with similar costing perspectives.

Indexed as

Financial StressStrokeCost of IllnessHealth Care CostsHumansIncomeUnited Statescost of illnesseconomic burdenhemorrhagicischemicstroketransient ischemic attack

Identifiers

PMID35027963
PMCPMC8742896

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.