Evidence map›Paper›PMID 35027961›Full record

ReviewJournal of medicine and life

Alcoholic liver disease-from steatosis to cirrhosis - a biochemistry approach.

Ruxandra Cioarca-Nedelcu, Valeriu Atanasiu, Irina Stoian

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of medicine and life. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Hepatoprotective Effect of Kaempferol-A Review.Molecules (Basel, Switzerland) · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Walnut (Nutrients · 2023
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ruxandra Cioarca-NedelcuBiochemistry Department, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.
Valeriu AtanasiuBiochemistry Department, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.
Irina StoianBiochemistry Department, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nowadays, chronic alcoholism and its health implications represent a global concern. Over three million deaths are linked to chronic alcohol intake every year. This article aims to spread awareness about the negative impact ethanol can have on almost every organ in the body, especially the liver. Understanding ethanol metabolism and the cellular pathways through which alcohol increases liver oxidative stress may prevent a broad spectrum of hepatic lesions such as steatosis, steatohepatitis, and, ultimately, cirrhosis. After a short review of ethanol metabolism and liver oxidative stress, each hepatic lesion will be individually discussed regarding the mechanism of apparition, treatment, and future targeted therapies.

Indexed as

Fatty LiverLiver Diseases, AlcoholicEthanolHumansLiverLiver CirrhosisOxidative StressEthanolA(2)C – 2-(2-methoxy ethoxy) ethyl 8-(cis-2-n-octylcyclopropyl)ADH – alcohol dehydrogenaseALDH2 – aldehyde dehydrogenase 2AMPK – adenosine monophosphate-activated protein kinaseCD14 – cluster of differentiationcirrhosisCYP2E1 – cytochrome P450 2E1DNA – deoxyribonucleic acidER – endoplasmic reticulumethanolGSH – glutathioneH2O2 – hydrogen peroxideHER – hydroxyethyl radicalHSC – hepatic stellate cellsJNK – Janus KinaseKC – Kupffer cellsLPS – lipopolysaccharidesMAA – malondialdehyde-acetaldehyde compoundsNADH – reduced nicotinamide adenine dinucleotideNAD+ – nicotinamide adenine dinucleotideNADPH – reduced nicotinamide adenine dinucleotide phosphateNADP+ – nicotinamide adenine dinucleotide phosphateO2-∙ – superoxide anion-OH – hydroxyl radicaloxidative stressPPARalpha – peroxisome proliferator-activated receptor-alphaROS – reactive oxygen speciesSREBP-1 – sterol regulatory element-binding protein 1steatohepatitissteatosisTLR4 – toll-like receptor 4TNFalpha – tumor necrosis factor-alpha

Identifiers

PMID35027961
PMCPMC8742892

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.