ArticleFrontiers in human neuroscience2021
Resting-State Functional MRI Metrics in Patients With Chronic Mild Traumatic Brain Injury and Their Association With Clinical Cognitive Performance.
Article in Frontiers in human neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Resting-State Brain Activity Changes and Their Genetic Correlates in Mild Traumatic Brain Injury.Human brain mapping · 2025Pooled it
- Functional Connectivity Changes on Resting-State fMRI after Mild Traumatic Brain Injury: A Systematic Review.AJNR. American journal of neuroradiology · 2024Pooled it
- Resting-State Brain Entropy Reveals Altered Neural Dynamics and Cognitive Associations in Mild Traumatic Brain Injury: A Longitudinal Study.Journal of neuroscience research · 2026Article
- Longitudinal Multimodal Neuroimaging After Traumatic Brain Injury.Human brain mapping · 2026Article
- Altered spatial patterns of intrinsic brain activity and cognitive decline in colorectal cancer survivors.Journal of cancer survivorship : research and practice · 2026Article
- Animal Models of Traumatic Brain Injury and Their Relevance in Clinical Settings.CNS neuroscience & therapeutics · 2025Review
- The network-based underpinnings of persisting symptoms after concussion: a multimodal neuroimaging meta-analysis.Nature. Mental health · 2025Article
- Reorganization of brain networks in olfactory groove meningioma patients: a pilot resting-state fMRI study.Frontiers in neurology · 2025Article
- Changes in brain functional connectivity associated with transcutaneous auricular vagus nerve stimulation in healthy controls.Frontiers in human neuroscience · 2025Article
- Repetitive Mild Closed-Head Injury Induced Synapse Loss and Increased Local BOLD-fMRI Signal Homogeneity.Journal of neurotrauma · 2024Article
- Disruption of Resting-State Functional Connectivity in Acute Ischemic Stroke: Comparisons Between Right and Left Hemispheric Insults.Brain topography · 2024Article
- Cerebral Cortical Surface Structure and Neural Activation Pattern Among Adolescent Football Players.JAMA network open · 2024Article
- Treatment effects of N-acetyl cysteine on resting-state functional MRI and cognitive performance in patients with chronic mild traumatic brain injury: a longitudinal study.Frontiers in neurology · 2024Article
- Deep learning-based multimodality classification of chronic mild traumatic brain injury using resting-state functional MRI and PET imaging.Frontiers in neuroscience · 2023Article
- Reduction of Interhemispheric Homotopic Connectivity in Cognitive and Visual Information Processing Pathways in Patients With Thyroid-Associated Ophthalmopathy.Frontiers in human neuroscience · 2022Article
- Identification of chronic mild traumatic brain injury using resting state functional MRI and machine learning techniques.Frontiers in neuroscience · 2022Article
- The effect of general anesthesia on the test-retest reliability of resting-state fMRI metrics and optimization of scan length.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mild traumatic brain injury (mTBI) accounts for more than 80% of people experiencing brain injuries. Symptoms of mTBI include short-term and long-term adverse clinical outcomes. In this study, resting-state functional magnetic resonance imaging (rs-fMRI) was conducted to measure voxel-based indices including fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity (ReHo), and functional connectivity (FC) in patients suffering from chronic mTBI; 64 patients with chronic mTBI at least 3 months post injury and 40 healthy controls underwent rs-fMRI scanning. Partial correlation analysis controlling for age and gender was performed within mTBI cohort to explore the association between rs-fMRI metrics and neuropsychological scores. Compared with controls, chronic mTBI patients showed increased fALFF in the left middle occipital cortex (MOC), right middle temporal cortex (MTC), and right angular gyrus (AG), and increased ReHo in the left MOC and left posterior cingulate cortex (PCC). Enhanced FC was observed from left MOC to right precuneus; from right MTC to right superior temporal cortex (STC), right supramarginal, and left inferior parietal cortex (IPC); and from the seed located at right AG to left precuneus, left superior medial frontal cortex (SMFC), left MTC, left superior temporal cortex (STC), and left MOC. Furthermore, the correlation analysis revealed a significant correlation between neuropsychological scores and fALFF, ReHo, and seed-based FC measured from the regions with significant group differences. Our results demonstrated that alterations of low-frequency oscillations in chronic mTBI could be representative of disruption in emotional circuits, cognitive performance, and recovery in this cohort.
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