Evidence map›Paper›PMID 35027678›Full record

ArticleMolecular psychiatry2022

Spatial and temporal dynamics of HDACs class IIa following mild traumatic brain injury in adult rats.

Swatabdi R Kamal, Shreya Potukutchi, David J Gelovani, Robin E Bonomi, Srinivasu Kallakuri, John M Cavanaugh, Thomas Mangner, Alana Conti, Ren-Shyan Liu, Renata Pasqualini and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Swatabdi R KamalDepartment of Biomedical Engineering, College of Engineering and School of Medicine, Wayne State University, Detroit, MI, 48201, USA.
Shreya PotukutchiDepartment of Biomedical Engineering, College of Engineering and School of Medicine, Wayne State University, Detroit, MI, 48201, USA.
David J GelovaniSchool of Medicine, Wayne State University, Detroit, MI, 48201, USA.
Robin E BonomiSchool of Medicine, Wayne State University, Detroit, MI, 48201, USA.
Srinivasu KallakuriDepartment of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, MI, 48201, USA.
John M CavanaughDepartment of Biomedical Engineering, College of Engineering and School of Medicine, Wayne State University, Detroit, MI, 48201, USA.
Thomas MangnerCyclotron-Radiochemistry Facility, Karmanos Cancer Institute, Wayne State University, Detroit, MI, 48201, USA.
Alana ContiResearch and Development Service, John D. Dingell VA Medical Center, Detroit, MI, 48201, USA.
Ren-Shyan LiuDepartment of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.
Renata PasqualiniDivision of Cancer Biology, Department of Radiation Oncology, Rutgers New Jersey Medical School, Newark, NJ, 07103, USA.
Wadih ArapRutgers Cancer Institute of New Jersey, Newark, NJ, 07103, USA.
Richard L SidmanDepartment of Neurology, Harvard Medical School, Boston, MA, 02115, USA.
Shane A PerrineDepartment of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, MI, 48201, USA.
Juri G GelovaniDepartment of Biomedical Engineering, College of Engineering and School of Medicine, Wayne State University, Detroit, MI, 48201, USA. jgelovani@uaeu.ac.ae.ORCID http://orcid.org/0000-0002-8413-6161
Wayne State University · USRutgers, The State University of New Jersey · USHarvard University · USNational Yang Ming Chiao Tung University · TW

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI Jennifer L Beebe-Dimmer · 1985 to 2026
$68.4M
Effects of cocaine taking and seeking on histone deacetylase class IIa enzyme activity in the nucleus accumbens of ratsR01DA042057 · NIDA · WAYNE STATE UNIVERSITY · PI PERRINE, SHANE ALAN · 2017 to 2021
$3.0M
NCI NIH HHS P30 CA022453NIDA NIH HHS R01 DA042057RRD VA I21 RX002900
6 · The paper itself

Abstract

The fundamental role of epigenetic regulatory mechanisms involved in neuroplasticity and adaptive responses to traumatic brain injury (TBI) is gaining increased recognition. TBI-induced neurodegeneration is associated with several changes in the expression-activity of various epigenetic regulatory enzymes, including histone deacetylases (HDACs). In this study, PET/CT with 6-([

Indexed as

Brain ConcussionPositron Emission Tomography Computed TomographyAnilidesAnimalsEpigenesis, GeneticFluoroacetatesHistone DeacetylasesRats6-(trifluoroacetamido)-1-hexanoicanilideAnilidesFluoroacetatesHdac5 protein, ratHistone Deacetylases

Identifiers

PMID35027678
PMCPMC11629393
OpenAlexW4205916843

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.