Evidence map›Paper›PMID 35027669›Full record

ArticleOncogene2022

Exosomal circCARM1 from spheroids reprograms cell metabolism by regulating PFKFB2 in breast cancer.

Yonglei Liu, Li Ma, Fanli Hua, Zhihui Min, Yanxia Zhan, Wei Zhang, Junxia Yao

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Article
  3. Circular RNAs: key regulators in cancer stem cell dynamics.Molecular genetics and genomics : MGG · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yonglei LiuMedical Research Center, Zhongshan Hospital Qingpu Branch, Fudan University, Shanghai, China. yongleiliu@yeah.net.ORCID http://orcid.org/0000-0002-1904-0518
Li Ma *Medical Research Center, Zhongshan Hospital Qingpu Branch, Fudan University, Shanghai, China.
Fanli Hua *Department of Hematology, Zhongshan Hospital Qingpu Branch, Fudan University, Shanghai, China.
Zhihui MinInstitute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai, China.
Yanxia ZhanDepartment of Hematology, Zhongshan Hospital, Fudan University, Shanghai, China.
Wei ZhangInstitute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai, China.
Junxia YaoDepartment of Pathology, Zhongshan Hospital Qingpu Branch, Fudan University, Shanghai, China.
Sun Yat-sen University · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer stem cells (CSC) are the major obstacle for cancer therapy in clinic. Exosomes are one type of vesicles that containing circular RNA (circRNAs) involved in cell-cell communication. However, the roles of breast CSC (BCSC) exosomes are still unclear, and the purpose of the study was to investigate breast cancer cell metabolism reprogramming by circRNAs from BCSC exosomes. The circRNA array was performed in the exosomes secreted from spheroids of MDA-231 cells. circCARM1 was higher in BCSC exosomes than it in the parent breast cancer cells. Further investigation demonstrated that BCSC exosomes circCARM1 played an important role in breast cancer cell glycolysis by miR-1252-5p/PFKFB2. In a conclusion, BCSC exosome-derived circCARM1 played an important role in breast cancer cell glycolysis by sponging miR-1252-5p which regulated PFKFB2 expression.

Indexed as

Breast NeoplasmsExosomesMicroRNAsCell Line, TumorCell MovementFemaleHumansPhosphofructokinase-2MicroRNAsPFKFB2 protein, humanPhosphofructokinase-2

Identifiers

PMID35027669
OpenAlexW4205165876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.