ArticleCommunications biology2022
Lifespan prolonging mechanisms and insulin upregulation without fat accumulation in long-lived reproductives of a higher termite.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-Analysis of Public RNA Sequencing Data Revealed Potential Key Genes Associated with Reproductive Division of Labor in Social Hymenoptera and Termites.International journal of molecular sciences · 2023Pooled it
- Genome Evolution in Social Insects.Genome biology and evolution · 2026Review
- Transcriptomic Evidence Reveals the IIS-FOXO-SOD2 Axis as a Core Anti-Aging Pathway in Long-Lived Queens ofInsects · 2026Article
- Insect Lipidomics: Advances, Applications, and Physiological Insights.Advances in experimental medicine and biology · 2026Review
- Nature's blueprint for sugar metabolism: translating bee and ant strategies into human diabetes therapies.Diabetology & metabolic syndrome · 2025Review
- Extended longevity of termite kings and queens is accompanied by extranuclear localization of telomerase in somatic organs and caste-specific expression of its isoforms.Insect science · 2025Article
- Shaping the tripartite symbiosis: are termite microbiome functions directed by the environmentally acquired fungal cultivar?Animal microbiome · 2024Article
- Article
- A genetic toolkit underlying the queen phenotype in termites with totipotent workers.Scientific reports · 2024Article
- Selective enrichment of founding reproductive microbiomes allows extensive vertical transmission in a fungus-farming termite.Proceedings. Biological sciences · 2023Article
- Cell type specific polyploidization in the royal fat body of termite queens.Zoological letters · 2023Article
- The royal food of termites shows king and queen specificity.PNAS nexus · 2023Article
- Evolution of a Cockroach Allergen into the Major Protein of Termite Royal Jelly.International journal of molecular sciences · 2023Article
- GPR19 Coordinates Multiple Molecular Aspects of Stress Responses Associated with the Aging Process.International journal of molecular sciences · 2023Article
- The remoulding of dietary effects on the fecundity / longevity trade-off in a social insect.BMC genomics · 2023Article
- Article
- Insulin signaling in the long-lived reproductive caste of ants.Science (New York, N.Y.) · 2022Article
- The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance?Biomedicines · 2022Review
- Complex regulatory role of DNA methylation in caste- and age-specific expression of a termite.Open biology · 2022Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Kings and queens of eusocial termites can live for decades, while queens sustain a nearly maximal fertility. To investigate the molecular mechanisms underlying their long lifespan, we carried out transcriptomics, lipidomics and metabolomics in Macrotermes natalensis on sterile short-lived workers, long-lived kings and five stages spanning twenty years of adult queen maturation. Reproductives share gene expression differences from workers in agreement with a reduction of several aging-related processes, involving upregulation of DNA damage repair and mitochondrial functions. Anti-oxidant gene expression is downregulated, while peroxidability of membranes in queens decreases. Against expectations, we observed an upregulated gene expression in fat bodies of reproductives of several components of the IIS pathway, including an insulin-like peptide, Ilp9. This pattern does not lead to deleterious fat storage in physogastric queens, while simple sugars dominate in their hemolymph and large amounts of resources are allocated towards oogenesis. Our findings support the notion that all processes causing aging need to be addressed simultaneously in order to prevent it.
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