Evidence map›Paper›PMID 35027607›Full record

ArticleScientific reports2022

Oral streptococci subvert the host innate immune response through hydrogen peroxide.

Yi Ling Tang, Tiow Suan Sim, Kai Soo Tan

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Frontiers in cellular and infection microbiology · 2025
    Review
  8. Review
  9. Article
  10. Macrophage adaptation to hypoxia: metabolism, migration, and phagocytosis.Frontiers in cellular and infection microbiology · 2025
    Article
  11. Article
  12. Experimental Inoculation ofInternational journal of molecular sciences · 2024
    Article
  13. Insights into the enigma of oral streptococci in carcinogenesis.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  14. Commensal Oral Microbiota, Disease Severity, and Mortality in Fibrotic Lung Disease.American journal of respiratory and critical care medicine · 2024
    Article
  15. Oral streptococci: modulators of health and disease.Frontiers in cellular and infection microbiology · 2024
    Review
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yi Ling TangFaculty of Dentistry, National University of Singapore, Singapore, Singapore.
Tiow Suan SimDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Kai Soo TanFaculty of Dentistry, National University of Singapore, Singapore, Singapore. denkst@nus.edu.sg.
National University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In periodontal health, oral streptococci constitute up to 80% of the plaque biofilm. Yet, destructive inflammatory events of the periodontium are rare. This observation suggests that oral streptococci may possess mechanisms to co-exist with the host. However, the mechanisms employed by oral streptococci to modulate the innate immune response have not been well studied. One of the key virulence factors produced by oral streptococci is hydrogen peroxide (H

Indexed as

Immunity, InnateAnimalsHumansHydrogen PeroxideInflammationMacrophagesMiceMouth MucosaNF-E2-Related Factor 2NF-kappa BPeriodontiumRAW 264.7 CellsSignal TransductionStreptococcusHydrogen PeroxideNFE2L2 protein, humanNF-E2-Related Factor 2NF-kappa B

Identifiers

PMID35027607
PMCPMC8758666
OpenAlexW4206462846

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.