SynthesisScientific reports2022
Longer than 2 hours to antibiotics is associated with doubling of mortality in a multinational community-acquired bacterial meningitis cohort.
Synthesis in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Early vs. delayed empiric antimicrobial treatment for suspected acute meningitis - a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Shorter versus longer duration of antibiotic treatment in children with bacterial meningitis: a systematic review and meta-analysis.European journal of pediatrics · 2024Pooled it
- Delayed diagnosis is associated with complications following invasive meningococcal disease in Australian adolescents and young adults.Infection · 2026Article
- Fatal inflammation: understanding meningitis mortality in the United States (1999-2020).BMC neurology · 2026Observational
- Epidemiology and Clinical Outcomes of Meningococcal Infections in Japan: A Nationwide Inpatient Database Study From 2010 to 2023.Journal of epidemiology · 2026Article
- Disease burden of Streptococcus pneumoniae and Neisseria meningitidis meningitis in children and adolescents: A population-based study.Medicine · 2026Article
- From Presentation to Prognosis: Case-Based Learning in Pediatric Bacterial Meningitis for Postgraduate Training.MedEdPORTAL : the journal of teaching and learning resources · 2026Article
- [Infectious and inflammatory diseases of the central nervous system 2014-2024].Revista medica del Instituto Mexicano del Seguro Social · 2026Observational
- Concomitant infectious foci in community-acquired bacterial meningitis: the clinical impact of concomitant spondylitis and endocarditis.BMC infectious diseases · 2025Article
- Conceptual Methodological Framework for Incorporating Antimicrobial Resistance Considerations in Economic Models for Pneumococcal Conjugate Vaccines.Infectious diseases and therapy · 2025Article
- Initial management and outcome of community-acquired bacterial meningitis in two French ICUs over a period of fifteen years.BMC infectious diseases · 2025Observational
- Article
- A Multiplex Polymerase Chain Reaction Assay for the Detection of Herpes Simplex Virus, Cytomegalovirus, and Varicella-Zoster Virus in Cerebrospinal Fluid.Microorganisms · 2025Article
- Multiplexing the Identification of Microorganisms via Tandem Mass Tag Labeling Augmented by Interference Removal through a Novel Modification of the Expectation Maximization Algorithm.Journal of the American Society for Mass Spectrometry · 2024Article
- Exploring the Health-Related Quality of Life and the Lived Experience of Adolescents Following Invasive Meningococcal Disease.Healthcare (Basel, Switzerland) · 2024Article
- Factors contributing to the non-identification of bacterial meningitis in febrile infants: A case series study.SAGE open medical case reports · 2024Article
- Practice patterns in pediatric infectious encephalopathy in four centers in Africa.Frontiers in pediatrics · 2024Article
- Pre-hospital symptoms associated with acute bacterial meningitis differs between children and adults.Scientific reports · 2023Article
- Addition of daptomycin for the treatment of pneumococcal meningitis: protocol for the AddaMAP study.BMJ open · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 8 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To optimally define the association between time to effective antibiotic therapy and clinical outcomes in adult community-acquired bacterial meningitis. A systematic review of the literature describing the association between time to antibiotics and death or neurological impairment due to adult community-acquired bacterial meningitis was performed. A retrospective cohort, multivariable and propensity-score based analyses were performed using individual patient clinical data from Australian, Danish and United Kingdom studies. Heterogeneity of published observational study designs precluded meta-analysis of aggregate data (I
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.