Evidence map›Paper›PMID 35027545›Full record

ArticleBDJ open2022

Dentin tubule occlusion by a 38% silver diamine fluoride gel: an in vitro investigation.

Andreas Kiesow, Matthias Menzel, Frank Lippert, Jason M Tanzer, Peter Milgrom

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BDJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05395065 (Evaluation of the Response of Caries Lesions in Dentin After Application of Silver Diamine Fluoride Gel and Sodium Fluoride Varnish), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05395065 completednot on this map

Evaluation of the Response of Caries Lesions in Dentin After Application of Silver Diamine Fluoride Gel and Sodium Fluoride Varnish: A Single Group Observational Study

TypeobservationalSponsorAdvantage Silver Dental Arrest, LLCRan2022 to 2024Enrolled237ConditionsDental Caries in ChildrenArmsSilver Diamine Fluoride/Sodium Fluoride Varnish
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Effects of Bleaching Protocols on the Esthetic Outcome and Surface Integrity of Enamel Treated With an Ammonia-Free Silver Fluoride Solution.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026
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  14. Silver diamine fluoride therapy for dental care.The Japanese dental science review · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Andreas KiesowDepartment of Biological and Macromolecular Materials, Characterization of Medical and Cosmetic Care Products Group, Fraunhofer Institute for Microstructure of Materials and Systems IMWS, Walter-Huelse-Strasse 1, Halle, 6120, Germany.
Matthias MenzelDepartment of Biological and Macromolecular Materials, Characterization of Medical and Cosmetic Care Products Group, Fraunhofer Institute for Microstructure of Materials and Systems IMWS, Walter-Huelse-Strasse 1, Halle, 6120, Germany.
Frank LippertOral Health Research Institute, Department of Cariology, Operative Dentistry, and Dental Public Health, School of Dentistry, Indiana University, 415 Lansing Street, Indianapolis, IN, 46202-2876, USA.
Jason M TanzerDepartment of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT, 06030-1605, USA.
Peter MilgromDepartment of Oral Health Sciences, School of Dentistry, University of Washington, Seattle, WA, 98195-7475, USA. dfrc@uw.edu.ORCID http://orcid.org/0000-0003-0784-9181
Fraunhofer Institute for Microstructure of Materials and Systems · DEIndiana University – Purdue University Indianapolis · USUConn Health · USUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSilver diamine fluoride (SDF) is effective in treatment of dentin hypersensitivity and caries lesions. However, the non-viscous solution does not easily allow clinicians to control the application area. A 38% SDF experiment gel was compared in vitro to commercial SDF for its ability to penetrate and occlude dentinal tubules. MATERIALS AND

methodsHuman root surface dentin specimens were treated with gelled or standard 38% SDF or negative control. Penetration behavior was established by Drop Shape Analysis. Precipitates at the surface and within tubules were analyzed by SEM and EDX after treatment; Results: penetration depths up to 500 µm were observed for both SDF formulations. Both formulations occluded dentinal tubules similarly. Precipitates on the dentin surface and within dentinal tubules were found for both SDF formulations, with a slight tendency for the experimental gel SDF product to be more abundant than the commercially available one. DISCUSSION: behavior of the experimental 38% SDF gel formulation appeared indistinguishable from the commercial 38% SDF product with respect to dentinal tubule penetration and occlusion.

conclusionsThe experimental 38% SDF gel may be a suitable intervention for the prevention of dentin hypersensitivity.

Identifiers

PMID35027545
PMCPMC8758751
OpenAlexW4206663975

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.