ArticleNature communications2022
An intronic transposon insertion associates with a trans-species color polymorphism in Midas cichlid fishes.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 36 citations in OpenAlex.
- Two melanic pigment patterns are associated with a sex chromosome-linked oncogene in the mountain swordtailbioRxiv : the preprint server for biology · 2026Article
- Transposons drove the evolution of a male sex-determining gene from a female gene with deep introgression across cichlids.Science advances · 2026Article
- A genomic compendium of hundreds of teleost fishes reveals their evolutionary landscape.Innovation (Cambridge (Mass.)) · 2026Article
- Patterns and Processes of Genomic Evolution Inferred From the Ten Smallest Vertebrate Genomes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Insights into the genetic basis of bilateral head asymmetry in a scale-eating cichlid fish.Science advances · 2025Article
- Article
- Impact of the 294 bp SINE Insertion in 5'UTR of theAnimals : an open access journal from MDPI · 2025Article
- Lake Malawi cichlid pangenome graph reveals extensive structural variation driven by transposable elements.Genome research · 2025Article
- Bilateral asymmetry in craniofacial structures and kinematics of feeding attacks in the scale-eating cichlid fish,Zoological research · 2025Article
- Dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes.Genome biology · 2025Article
- Structural genomic variation and behavioral interactions underpin a balanced sexual mimicry polymorphism.Current biology : CB · 2024Article
- Remarkably High Repeat Content in the Genomes of Sparrows: The Importance of Genome Assembly Completeness for Transposable Element Discovery.Genome biology and evolution · 2024Article
- Dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes.bioRxiv : the preprint server for biology · 2024Article
- Genome editing in East African cichlids and tilapias: state-of-the-art and future directions.Open biology · 2023Review
- SINE Insertion in the Pig Carbonic Anhydrase 5BAnimals : an open access journal from MDPI · 2023Article
- Morphological and temporal variation in early embryogenesis contributes to species divergence in Malawi cichlid fishes.Evolution & development · 2023Article
- Noncanonical DNA structures are drivers of genome evolution.Trends in genetics : TIG · 2023Review
- Advances in Vertebrate (Cyto)Genomics Shed New Light on Fish Compositional Genome Evolution.Genes · 2023Article
- East African cichlid fishes.EvoDevo · 2023Review
- Transposable elements and xenobiotic resistance.Frontiers in insect science · 2023Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polymorphisms have fascinated biologists for a long time, but their genetic underpinnings often remain elusive. Here, we aim to uncover the genetic basis of the gold/dark polymorphism that is eponymous of Midas cichlid fish (Amphilophus spp.) adaptive radiations in Nicaraguan crater lakes. While most Midas cichlids are of the melanic "dark morph", about 10% of individuals lose their melanic pigmentation during their ontogeny and transition into a conspicuous "gold morph". Using a new haplotype-resolved long-read assembly we discover an 8.2 kb, transposon-derived inverted repeat in an intron of an undescribed gene, which we term goldentouch in reference to the Greek myth of King Midas. The gene goldentouch is differentially expressed between morphs, presumably due to structural implications of inverted repeats in both DNA and/or RNA (cruciform and hairpin formation). The near-perfect association of the insertion with the phenotype across independent populations suggests that it likely underlies this trans-specific, stable polymorphism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.