Evidence map›Paper›PMID 35027445›Full record

ArticleeNeuro

Lyso-Lipid-Induced Oligodendrocyte Maturation Underlies Restoration of Optic Nerve Function.

Anddre Osmar Valdivia, Sanjoy K Bhattacharya

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Anddre Osmar ValdiviaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, Florida 33136.ORCID 0000-0002-8425-9102
Sanjoy K BhattacharyaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, Florida 33136 sbhattacharya@med.miami.edu.ORCID 0000-0003-3759-647X
University of Miami · US

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Dmitry V Ivanov · 2004 to 2026
$12.2M
Novel Targets to Promote RGC Axon Regeneration: Insights from Unique RGC CohortsU01EY027257 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BHATTACHARYA, SANJOY K, LEMMON, VANCE P · 2016 to 2018
$2.0M
NEI NIH HHS P30 EY014801NEI NIH HHS U01 EY027257
6 · The paper itself

Abstract

Protein hyperdeimination and deficiency of lyso-phospholipids (LPC 18:1) has been associated with the pathology of demyelinating disease in both humans and mice. We uncovered interesting biology of LPC 18:1, in which LPC 18:1 induced optic nerve function restoration through oligodendrocyte maturation and remyelination in mouse model systems. Our

Indexed as

Demyelinating DiseasesAnimalsCell DifferentiationLipidsMiceMice, Inbred C57BLMyelin SheathOligodendrogliaOptic NerveLipidsdeiminationLPC 18:1myelinoligodendrocytesoptic nerveremyelination

Identifiers

PMID35027445
PMCPMC8805197
OpenAlexW4205097681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.