ArticleJournal of psychiatry & neuroscience : JPN
Investigating structural subdivisions of the anterior cingulate cortex in schizophrenia, with implications for treatment resistance and glutamatergic levels.
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Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15citing papers in PubMed, 1 pooled it
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Rational and Translational Implications of D-Amino Acids for Treatment-Resistant Schizophrenia: From Neurobiology to the Clinics.Biomolecules · 2022Pooled it
- Beyond Clozapine Failure: Precision Approach and Palliative Psychiatry in Ultra-Treatment-Resistant Schizophrenia.Journal of clinical medicine · 2026Review
- Elevated glutamine but not glutamate is associated with clozapine eligibility in an early psychosis sample.Frontiers in psychiatry · 2026Article
- Taming dimensionality in big neuroimaging data: Efficient orthonormal projective NMF via stochastic learning and data compression.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Molecular Underpinning of Treatment-Resistant Schizophrenia: A Putative Different Neurobiology from Treatment-Responsive Schizophrenia.International journal of molecular sciences · 2025Review
- The role of affective states in computational psychiatry.The international journal of neuropsychopharmacology · 2025Review
- Cognitive-and lifestyle-related microstructural variation in the ageing human hippocampus.Brain structure & function · 2025Article
- Addressing brain metabolic connectivity in treatment-resistant schizophrenia: a novel graph theory-driven application ofSchizophrenia (Heidelberg, Germany) · 2024Article
- Longitudinal trajectories of anterior cingulate glutamate and subclinical psychotic experiences in early adolescence: the impact of bullying victimization.Molecular psychiatry · 2024Article
- Disease Progression Patterns of Brain Morphology in Schizophrenia: More Progressed Stages in Treatment Resistance.Schizophrenia bulletin · 2024Article
- Development of white matter fiber covariance networks supports executive function in youth.Cell reports · 2023Article
- A systematic review of neuroimaging studies of clozapine-resistant schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Review
- Development of White Matter Fiber Covariance Networks Supports Executive Function in Youth.bioRxiv : the preprint server for biology · 2023Article
- Scalable NMF via linearly optimized data compression.Proceedings of SPIE--the International Society for Optical Engineering · 2023Article
- Scalable Orthonormal Projective NMF via Diversified Stochastic Optimization.Information processing in medical imaging : proceedings of the ... conference · 2023Article
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Authors and funding
15 authors at 5 institutions in 2 countries.
Ryo OchiFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Ochi, Tarumi, Tsugawa, Honda, Noda, Uchida, Mimura, Nakajima); the Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Que., Canada (Plitman, Patel, Devenyi, Chakravarty); the Department of Psychiatry, McGill University, Montreal, Que., Canada (Plitman, Devenyi, Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Que., Canada (Patel, Chakravarty); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Iwata, Kim, Graff-Guerrero, Nakajima); and the Institute of Medical Science, University of Toronto, Toronto, Ont., Canada (Kim, Graff-Guerrero).
Eric PlitmanFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Ochi, Tarumi, Tsugawa, Honda, Noda, Uchida, Mimura, Nakajima); the Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Que., Canada (Plitman, Patel, Devenyi, Chakravarty); the Department of Psychiatry, McGill University, Montreal, Que., Canada (Plitman, Devenyi, Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Que., Canada (Patel, Chakravarty); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Iwata, Kim, Graff-Guerrero, Nakajima); and the Institute of Medical Science, University of Toronto, Toronto, Ont., Canada (Kim, Graff-Guerrero).
Raihaan PatelFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Ochi, Tarumi, Tsugawa, Honda, Noda, Uchida, Mimura, Nakajima); the Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Que., Canada (Plitman, Patel, Devenyi, Chakravarty); the Department of Psychiatry, McGill University, Montreal, Que., Canada (Plitman, Devenyi, Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Que., Canada (Patel, Chakravarty); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Iwata, Kim, Graff-Guerrero, Nakajima); and the Institute of Medical Science, University of Toronto, Toronto, Ont., Canada (Kim, Graff-Guerrero).
Ryosuke TarumiFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Ochi, Tarumi, Tsugawa, Honda, Noda, Uchida, Mimura, Nakajima); the Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Que., Canada (Plitman, Patel, Devenyi, Chakravarty); the Department of Psychiatry, McGill University, Montreal, Que., Canada (Plitman, Devenyi, Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Que., Canada (Patel, Chakravarty); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Iwata, Kim, Graff-Guerrero, Nakajima); and the Institute of Medical Science, University of Toronto, Toronto, Ont., Canada (Kim, Graff-Guerrero).
Yusuke IwataFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Ochi, Tarumi, Tsugawa, Honda, Noda, Uchida, Mimura, Nakajima); the Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Que., Canada (Plitman, Patel, Devenyi, Chakravarty); the Department of Psychiatry, McGill University, Montreal, Que., Canada (Plitman, Devenyi, Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Que., Canada (Patel, Chakravarty); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Iwata, Kim, Graff-Guerrero, Nakajima); and the Institute of Medical Science, University of Toronto, Toronto, Ont., Canada (Kim, Graff-Guerrero).
Sakiko TsugawaFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Ochi, Tarumi, Tsugawa, Honda, Noda, Uchida, Mimura, Nakajima); the Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Que., Canada (Plitman, Patel, Devenyi, Chakravarty); the Department of Psychiatry, McGill University, Montreal, Que., Canada (Plitman, Devenyi, Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Que., Canada (Patel, Chakravarty); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Iwata, Kim, Graff-Guerrero, Nakajima); and the Institute of Medical Science, University of Toronto, Toronto, Ont., Canada (Kim, Graff-Guerrero).
Julia KimFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Ochi, Tarumi, Tsugawa, Honda, Noda, Uchida, Mimura, Nakajima); the Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Que., Canada (Plitman, Patel, Devenyi, Chakravarty); the Department of Psychiatry, McGill University, Montreal, Que., Canada (Plitman, Devenyi, Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Que., Canada (Patel, Chakravarty); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Iwata, Kim, Graff-Guerrero, Nakajima); and the Institute of Medical Science, University of Toronto, Toronto, Ont., Canada (Kim, Graff-Guerrero).
Shiori HondaFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Ochi, Tarumi, Tsugawa, Honda, Noda, Uchida, Mimura, Nakajima); the Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Que., Canada (Plitman, Patel, Devenyi, Chakravarty); the Department of Psychiatry, McGill University, Montreal, Que., Canada (Plitman, Devenyi, Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Que., Canada (Patel, Chakravarty); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Iwata, Kim, Graff-Guerrero, Nakajima); and the Institute of Medical Science, University of Toronto, Toronto, Ont., Canada (Kim, Graff-Guerrero).
Yoshihiro NodaFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Ochi, Tarumi, Tsugawa, Honda, Noda, Uchida, Mimura, Nakajima); the Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Que., Canada (Plitman, Patel, Devenyi, Chakravarty); the Department of Psychiatry, McGill University, Montreal, Que., Canada (Plitman, Devenyi, Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Que., Canada (Patel, Chakravarty); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Iwata, Kim, Graff-Guerrero, Nakajima); and the Institute of Medical Science, University of Toronto, Toronto, Ont., Canada (Kim, Graff-Guerrero).
Hiroyuki UchidaFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Ochi, Tarumi, Tsugawa, Honda, Noda, Uchida, Mimura, Nakajima); the Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Que., Canada (Plitman, Patel, Devenyi, Chakravarty); the Department of Psychiatry, McGill University, Montreal, Que., Canada (Plitman, Devenyi, Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Que., Canada (Patel, Chakravarty); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Iwata, Kim, Graff-Guerrero, Nakajima); and the Institute of Medical Science, University of Toronto, Toronto, Ont., Canada (Kim, Graff-Guerrero).
Gabriel A DevenyiFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Ochi, Tarumi, Tsugawa, Honda, Noda, Uchida, Mimura, Nakajima); the Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Que., Canada (Plitman, Patel, Devenyi, Chakravarty); the Department of Psychiatry, McGill University, Montreal, Que., Canada (Plitman, Devenyi, Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Que., Canada (Patel, Chakravarty); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Iwata, Kim, Graff-Guerrero, Nakajima); and the Institute of Medical Science, University of Toronto, Toronto, Ont., Canada (Kim, Graff-Guerrero).
Masaru MimuraFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Ochi, Tarumi, Tsugawa, Honda, Noda, Uchida, Mimura, Nakajima); the Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Que., Canada (Plitman, Patel, Devenyi, Chakravarty); the Department of Psychiatry, McGill University, Montreal, Que., Canada (Plitman, Devenyi, Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Que., Canada (Patel, Chakravarty); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Iwata, Kim, Graff-Guerrero, Nakajima); and the Institute of Medical Science, University of Toronto, Toronto, Ont., Canada (Kim, Graff-Guerrero).
Ariel Graff-GuerreroFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Ochi, Tarumi, Tsugawa, Honda, Noda, Uchida, Mimura, Nakajima); the Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Que., Canada (Plitman, Patel, Devenyi, Chakravarty); the Department of Psychiatry, McGill University, Montreal, Que., Canada (Plitman, Devenyi, Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Que., Canada (Patel, Chakravarty); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Iwata, Kim, Graff-Guerrero, Nakajima); and the Institute of Medical Science, University of Toronto, Toronto, Ont., Canada (Kim, Graff-Guerrero).
M Mallar ChakravartyFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Ochi, Tarumi, Tsugawa, Honda, Noda, Uchida, Mimura, Nakajima); the Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Que., Canada (Plitman, Patel, Devenyi, Chakravarty); the Department of Psychiatry, McGill University, Montreal, Que., Canada (Plitman, Devenyi, Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Que., Canada (Patel, Chakravarty); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Iwata, Kim, Graff-Guerrero, Nakajima); and the Institute of Medical Science, University of Toronto, Toronto, Ont., Canada (Kim, Graff-Guerrero).
Shinichiro NakajimaFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Ochi, Tarumi, Tsugawa, Honda, Noda, Uchida, Mimura, Nakajima); the Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Que., Canada (Plitman, Patel, Devenyi, Chakravarty); the Department of Psychiatry, McGill University, Montreal, Que., Canada (Plitman, Devenyi, Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Que., Canada (Patel, Chakravarty); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Iwata, Kim, Graff-Guerrero, Nakajima); and the Institute of Medical Science, University of Toronto, Toronto, Ont., Canada (Kim, Graff-Guerrero) shinichiro_nakajima@hotmail.com.
Keio University · JPCentre for Addiction and Mental Health · CAMcGill University · CAUniversity of Toronto · CAHonda (Japan) · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbnormalities in the anterior cingulate cortex (ACC) are thought to play an important role in the pathophysiology of schizophrenia. Given regional variations in ACC structure, the present study aimed to examine ACC structural subdivisions and their relationships to treatment resistance and glutamatergic levels in schizophrenia.
methodsThis study included 100 patients with schizophrenia and 52 healthy controls from 2 cohorts. We applied non-negative matrix factorization to identify accurate and stable spatial components of ACC structure. Between groups, we compared ACC structural indices in each spatial component based on treatment resistance or response and tested relationships with ACC glutamate + glutamine levels.
resultsWe detected reductions in cortical thickness and increases in mean diffusivity in the spatial components on the surface of the cingulate sulcus, especially in patients with treatment-resistant and clozapine-resistant schizophrenia. Notably, mean diffusivity in these components was higher in patients who did not respond to clozapine compared to those who did. Furthermore, these ACC structural alterations were related to elevated ACC glutamate + glutamine levels but not related to symptomatology or antipsychotic dose. LIMITATIONS: Sample sizes, cross-sectional findings and mixed antipsychotic status were limitations of this study.
conclusionThis study identified reproducible abnormalities in ACC structures in patients with treatment-resistant and clozapine-resistant schizophrenia. Given that these spatial components play a role in inhibitory control, the present study strengthens the notion that glutamate-related disinhibition is a common biological feature of treatment resistance in schizophrenia.
Indexed as
Antipsychotic AgentsClozapineSchizophreniaCross-Sectional StudiesGlutamic AcidGlutamineGyrus CinguliHumansAntipsychotic AgentsClozapineGlutamic AcidGlutamine
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