Evidence map›Paper›PMID 35027409›Full record

ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Neuroimmunometabolism: A New Pathological Nexus Underlying Neurodegenerative Disorders.

Swarup Mitra, Avijit Banik, Sumit Saurabh, Malabika Maulik, Shailesh N Khatri

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

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  18. Microglial immunometabolism endophenotypes contribute to sex difference in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Swarup MitraDepartment of Pharmacology & Toxicology, Jacob School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York 14203.
Avijit BanikDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia 30322 avijit.banik@emory.edu avibanik@yahoo.co.in.
Sumit SaurabhDepartment of Biology, Loyola University, Chicago, Illinois 60660.
Malabika MaulikDepartment of Biotechnical and Clinical Laboratory Sciences, State University of New York at Buffalo, Buffalo, New York 14226.
Shailesh N KhatriDepartment of Family and Community Medicine, University of Kentucky College of Medicine, University of Kentucky, Lexington, Kentucky 40508.
Loyola University Chicago · USUniversity of Kentucky · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroimmunometabolism is an emerging field that examines the intersection of immunologic and metabolic cascades in the brain. Neuroinflammatory conditions often involve differential metabolic reprogramming in neuronal and glial cells through their immunometabolic sensors. The impact of such bioenergetic adaptation on general brain function is poorly understood, but this cross-talk becomes increasingly important in neurodegenerative disorders that exhibit reshaping of neuroimmunometabolic pathways. Here we summarize the intrinsic balance of neuroimmunometabolic substrates and sensors in the healthy brain and how their dysregulation can contribute to the pathophysiology of various neurodegenerative disorders. This review also proposes possible avenues for disease management through neuroimmunometabolic profiling and therapeutics to bridge translational gaps and guide future treatment strategies.

Indexed as

Central Nervous System DiseasesNeurodegenerative DiseasesBrainEnergy MetabolismHumansNeuronsimmunometabolic sensorsneurodegenerationneuroimmunometabolismneuroinflammation

Identifiers

PMID35027409
PMCPMC8916763
OpenAlexW4205396174

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.