Evidence map›Paper›PMID 35027368›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2022

SV2A PET Imaging Is a Noninvasive Marker for the Detection of Spinal Damage in Experimental Models of Spinal Cord Injury.

Daniele Bertoglio, Nicolas Halloin, Stef De Lombaerde, Aleksandar Jankovski, Jeroen Verhaeghe, Charles Nicaise, Steven Staelens

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. SV2A PET Imaging Detects Severity-Dependent Synaptic Changes After Experimental Traumatic Spinal Cord Injury.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  2. SV2A PET reveals synaptic density loss in experimental autoimmune encephalomyelitis and in a pilot multiple sclerosis study.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  5. Assessing non-invasive quantitative methods for [European journal of nuclear medicine and molecular imaging · 2025
    Article
  6. Imaging Demyelinated Axons After Spinal Cord Injuries with PET Tracer [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  7. Article
  8. Article
  9. Resting-State Functional MRI and PET Imaging as Noninvasive Tools to Study (Ab)Normal Neurodevelopment in Humans and Rodents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Review
  10. Validation, kinetic modeling, and test-retest reproducibility of [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Daniele BertoglioMolecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.
Nicolas HalloinURPhyM-NARILIS, University of Namur, Namur, Belgium.
Stef De LombaerdeMolecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.
Aleksandar JankovskiInstitute of NeuroScience, NEUR Division, Université Catholique de Louvain, Louvain, Belgium; and.
Jeroen VerhaegheMolecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.
Charles NicaiseURPhyM-NARILIS, University of Namur, Namur, Belgium.
Steven StaelensMolecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium; steven.staelens@uantwerpen.be.
University of Antwerp · BEUniversity of Namur · BECHU Dinant Godinne UCL Namur · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic spinal cord injury (SCI) is a neurologic condition characterized by long-term motor and sensory neurologic deficits as a consequence of an external physical impact damaging the spinal cord. Anatomic MRI is considered the gold-standard diagnostic tool to obtain structural information for the prognosis of acute SCI; however, it lacks functional objective information to assess SCI progression and recovery. In this study, we explored the use of synaptic vesicle glycoprotein 2A (SV2A) PET imaging to detect spinal cord lesions noninvasively after SCI.

Indexed as

ContusionsSpinal Cord InjuriesAnimalsBiomarkersFluorodeoxyglucose F18Membrane GlycoproteinsMiceModels, TheoreticalNerve Tissue ProteinsPositron-Emission TomographyPositron Emission Tomography Computed TomographyPyrrolidinonesRatsBiomarkersFluorodeoxyglucose F18Membrane GlycoproteinsNerve Tissue ProteinsPyrrolidinonesSv2a protein, rat11C-UCB-Janimal modelbiomarkercontusion SCISV2A

Identifiers

PMID35027368
PMCPMC9364338
OpenAlexW4206339832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.